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Injectable local drug delivery systems for glioblastoma: a systematic review and <i>meta</i>-analysis of progress to date.

Author: BastiancichChiara, NewlandBen, WangYu

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review explores the development and pre-clinical testing of injectable drug delivery systems (DDS) for local treatment of glioblastoma. The analysis of 36 original articles showed that local administration of injectable DDS was beneficial in increasing animal survival time, suggesting promising potential for future clinical translation.
Paper Details　
Original Abstract of the Article :
Glioblastoma (GBM) is an aggressive malignant cancer associated with bleak prognosis and high mortality. The current standard of care for GBM is maximum surgical resection plus radiotherapy and temozolomide (TMZ) chemotherapy. The blood brain barrier (BBB) remains the main obstacle for chemotherapy ...See full text at original site
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引用元：
https://doi.org/10.1039/d2bm01534j

データ提供：米国国立医学図書館（NLM）

Glioblastoma: Confronting the Brain Tumor Giant

Glioblastoma is a [malignant brain tumor] with an aggressive nature and a poor prognosis. This research explores the potential of [injectable local drug delivery systems] as a way to deliver chemotherapy directly to the tumor site, bypassing the [blood-brain barrier]. The study reviews pre-clinical studies investigating various [drug delivery systems] that can be injected directly into the brain tumor, aiming to improve treatment outcomes. These include [nanoparticles], [liposomes], [microspheres], and [hydrogels].

Targeting the Tumor: A Direct Approach

The study suggests that [injectable drug delivery systems] offer a promising strategy for treating [glioblastoma] by delivering chemotherapy directly to the tumor. This targeted approach could potentially reduce the side effects associated with systemic chemotherapy. The analysis of pre-clinical studies shows that [local drug delivery systems] can improve the survival time of animals with [glioblastoma].

Brain Tumor Treatment: Hope for the Future

This research offers hope for those battling [glioblastoma]. The development of more effective [drug delivery systems] could lead to improved treatment outcomes and potentially increase survival rates.

Dr. Camel's Conclusion

This research sheds light on the potential of [injectable local drug delivery systems] in the fight against [glioblastoma]. By overcoming the challenges of the [blood-brain barrier], these systems could revolutionize the treatment of this aggressive brain tumor. Imagine a camel caravan navigating a treacherous desert, carrying vital supplies to a remote oasis - much like these drug delivery systems, they carry hope and potential for healing.

Date :
  1. Date Completed 2023-03-01
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

36655634

DOI: Digital Object Identifier

10.1039/d2bm01534j

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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