Paper Details

  1. Home
  2. Paper Details

A randomized crossover comparison of acebutolol and methyldopa in the treatment of mild to moderate essential hypertension.

Author: ChatterjiA N

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol was more effective than methyldopa in reducing both systolic and diastolic blood pressures and pulse rate in patients with mild to moderate essential hypertension. Acebutolol was also associated with fewer side effects and had a potassium-sparing effect.
Paper Details　
Original Abstract of the Article :
In a randomized crossover comparison between acebutolol and methyldopa for the treatment of mild to moderate essential hypertension in 30 patients, acebutolol, a cardioselective beta-one-adrenergic blocker, at 400 to 800 mg daily was found to be significantly better (p less than 0.002) than 500 to 1...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1185/03007997809110206

データ提供：米国国立医学図書館（NLM）

Acebutolol vs. Methyldopa: A Race Through the Desert of Hypertension

Hypertension, or high blood pressure, is a significant health concern affecting millions worldwide. This research compares the effectiveness of two medications, acebutolol and methyldopa, in treating mild to moderate essential hypertension. It's a race through the desert of hypertension, seeking the most effective and well-tolerated treatment.

Acebutolol: A Superior Oasis in Hypertension

This study demonstrates that acebutolol, a cardioselective beta-one-adrenergic blocker, was more effective than methyldopa in reducing both systolic and diastolic blood pressure and pulse rate. Acebutolol was also associated with fewer side effects. It's like choosing the right camel for a long desert journey, acebutolol proved to be a more reliable and comfortable companion in the fight against hypertension.

The Importance of Personalized Treatment

These findings highlight the importance of personalized treatment approaches for hypertension. Different medications can have varying effects on individual patients, emphasizing the need for careful selection and monitoring. It's a reminder that even in the vast desert of hypertension, there are oases of relief waiting to be discovered for each individual.

Dr.Camel's Conclusion

This research underscores the importance of finding the right medication for hypertension, considering both efficacy and tolerability. Acebutolol appears to be a promising option for many patients, offering a more effective and well-tolerated approach to managing this common condition.

Date :
  1. Date Completed 1979-04-25
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

367712

DOI: Digital Object Identifier

10.1185/03007997809110206

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.