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Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options.

Author: BeckelJonathan, ChancellorMichael, ChermanskyChristopher, ChoKang Jun, GangulyAnirban, HashimotoMamoru, KanaiAnthony, KaufmanJonathan, TyagiPradeep, TyagiShachi, YoshimuraNaoki

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article focuses on the diagnosis and treatment of lower urinary tract symptoms in older adults. The challenges include neurodegenerative changes in the micturition reflex, age-related decline in liver and kidney function, and increased risk of adverse drug reactions. This article highlights the benefits of intravesical antimuscarinics over oral antimuscarinics in managing these symptoms.
Paper Details　
Original Abstract of the Article :
This article provides an overview of the diagnosis and the treatment of lower urinary tract symptoms in older adults complicated by the neurodegenerative changes in the micturition reflex and further confounded by age-related decline in hepatic and renal clearance raising the propensity of adverse d...See full text at original site
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引用元：
https://doi.org/10.1007/s40266-023-01009-5

データ提供：米国国立医学図書館（NLM）

Treating Lower Urinary Tract Symptoms in Older Adults

As we age, our bodies undergo a myriad of changes, like a desert landscape evolving over time. These changes can affect our urinary system, leading to lower urinary tract symptoms (LUTS), a common concern for older adults.

The traditional approach to treating LUTS has been to use oral antimuscarinic medications. However, these drugs can have significant side effects due to their widespread action on muscarinic receptors throughout the body. This is like trying to control a desert's wind by blocking its path at a single point, leading to unintended consequences.

A New Route: Intravesical Antimuscarinics

Intravesical antimuscarinics, delivered directly into the bladder, offer a more targeted approach. They achieve higher concentrations in the bladder, while minimizing systemic exposure, thereby reducing side effects. This is like directing water to a specific oasis in the desert, ensuring that it reaches its intended destination without impacting other areas.

The Promise of Intravesical Treatment

Our research highlights the potential of intravesical treatment for LUTS in older adults. This approach offers a more targeted and potentially safer alternative to traditional oral medications.

Dr. Camel's Conclusion

Intravesical antimuscarinics provide a promising new avenue for treating LUTS in older adults, minimizing systemic side effects and optimizing treatment efficacy. This research suggests a more targeted and personalized approach to managing this common age-related condition.

Date :
  1. Date Completed 2023-04-10
  2. Date Revised 2023-05-24
Further Info :

Pubmed ID

36879156

DOI: Digital Object Identifier

10.1007/s40266-023-01009-5

SNS
PICO Info
in preparation
Languages

English

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