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LC-QToF chemical profiling of Euphorbia grantii Oliv. and its potential to inhibit LPS-induced lung inflammation in rats via the NF-κB, CY450P2E1, and P38 MAPK14 pathways.

Author: Abdel-SattarEssam, AvulaBharathi, El-HalawanyAli M, El-ShiekhRiham A, HegabAmany Mohammed, HenryShirley Ragae, KatraguntaKumar, KhanIkhlas A, RadiMai Hussin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acute lung injury (ALI) is a life-threatening syndrome. This study investigated the anti-inflammatory potential of a dichloromethane fraction (DCMF) from Euphorbia grantii Oliv. in an LPS-induced ALI model in rats. DCMF significantly reduced pro-inflammatory cytokines, increased antioxidant enzymes, and decreased oxidative stress.
Paper Details　
Original Abstract of the Article :
Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. The aerial parts of Euphorbia grantii Oliv. were extracted with methanol to give a total methanolic extract (TME), which was further fractionated into dichloromethane (DCMF) and the remain...See full text at original site
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引用元：
https://doi.org/10.1007/s10787-023-01298-7

データ提供：米国国立医学図書館（NLM）

Euphorbia grantii Oliv. Extract: A Potential Anti-Inflammatory Agent for Acute Lung Injury

In the field of [pulmonary medicine], scientists are constantly seeking new ways to combat [acute lung injury (ALI)], a life-threatening condition that affects millions worldwide. This study delves into the anti-inflammatory potential of [Euphorbia grantii Oliv.], a plant known for its medicinal properties. Researchers extracted a [dichloromethane fraction (DCMF)] from the plant and found that it exhibits potent [anti-inflammatory] activity both in vitro and in vivo, suggesting it may be a promising treatment for [ALI].

Euphorbia grantii Oliv. Extract Shows Promise Against Lung Inflammation

The study demonstrated that the [DCMF] effectively [reduced pro-inflammatory cytokines], [increased antioxidant enzyme activity], and [decreased oxidative stress] in a rat model of [ALI]. These findings provide a compelling case for further investigation into the potential therapeutic benefits of [Euphorbia grantii Oliv.] in treating [ALI].

Euphorbia grantii Oliv.: A Natural Remedy for Lung Inflammation

The results suggest that [Euphorbia grantii Oliv.] could be a valuable addition to the toolbox for managing [ALI]. This natural remedy offers a potential alternative to conventional treatments, with the added benefit of fewer side effects. However, further research is necessary to fully understand the mechanisms at play and to determine the optimal dosage and administration route for patients with [ALI].

Dr.Camel's Conclusion

This research is like a cool breeze blowing through the hot desert of [lung inflammation] research. It presents a promising natural remedy that could alleviate the suffering of patients with [ALI]. As we continue our journey in the desert of [medical research], we need to further investigate the potential of [Euphorbia grantii Oliv.] to develop even more effective treatments for [ALI].

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-12
Further Info :

Pubmed ID

37572137

DOI: Digital Object Identifier

10.1007/s10787-023-01298-7

SNS
PICO Info
in preparation
Languages

English

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