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Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral).

Author: LittlerW A, WatsonR D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol, a beta-blocker, reduced resting and exercise heart rate and blood pressure within 90 minutes of the first dose, and these effects persisted for 24 hours after the fifth daily dose. While the effects were attenuated at 24 hours, a linear relationship was observed between serum drug levels and the percentage reduction in exercise heart rate.
Paper Details　
Original Abstract of the Article :
1. The onset and duration of action of once daily acebutolol (400 mg) on resting and exercise heart rate and blood pressure were studied in normal subjects in a double-blind, cross-over trial against placebo. Subjects were studied 1.5, 3, 8 and 24 h after the first dose and 24 h after the fifth dose...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1979.tb04642.x

データ提供：米国国立医学図書館（NLM）

Acebutolol: A Long-Lasting Beta-Blocker

High blood pressure can feel like a relentless desert wind, putting a strain on our cardiovascular system. Beta-blockers are often used to help calm these winds, but their duration of action can vary. This study investigates the effects of acebutolol, a type of beta-blocker, on heart rate and blood pressure over a 24-hour period. The researchers found that acebutolol, taken once a day, effectively lowers heart rate and blood pressure for up to 24 hours, but its effect is somewhat reduced by the end of the day. This suggests that while acebutolol is a powerful medication, it might not be the best choice for those seeking a consistently strong effect throughout the entire day.

Acebutolol: A Steady Breeze in the Desert of Hypertension

This research suggests that acebutolol can provide a steady, if not always persistent, calming effect on blood pressure. It emphasizes the need for ongoing monitoring and potential adjustments to the medication to ensure its effectiveness throughout the day.

Navigating the Desert of Hypertension

This research underscores the importance of managing blood pressure effectively. It reminds us that not all medications are created equal, and that finding the right medication and dosage for our individual needs is crucial. Just as a desert traveler needs to find the right path, we need to find the right approach to manage our health.

Dr. Camel's Conclusion

This study provides valuable insights into the action of acebutolol in managing hypertension. It highlights the medication's effectiveness in lowering blood pressure over 24 hours, but also emphasizes the need for careful monitoring and dosage adjustments to ensure consistent control. While acebutolol can offer a steady breeze in the desert of hypertension, it's important to collaborate with your doctor to find the most effective strategy for your individual needs.
Date :
  1. Date Completed 1979-10-17
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

37868

DOI: Digital Object Identifier

10.1111/j.1365-2125.1979.tb04642.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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