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The efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstruction.

Author: BuickB, KinneyC, LowryR C, McDevittD G, TaylorD R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 25 patients with chronic bronchitis and varying degrees of airway obstruction compared the effectiveness of theophylline, inhaled salbutamol, a combination of both, and placebo. The combination therapy was most effective, with only 1 patient requiring additional treatment compared to 9 with placebo, 8 with salbutamol, and 6 with theophylline. The combination therapy also showed significant improvements in lung function, while theophylline was slightly better than placebo, but salbutamol was not. Patients who tolerated placebo did not report subjective benefits from any of the active treatments. These findings suggest that combining theophylline and inhaled salbutamol is a more effective treatment option for chronic bronchitis with airway obstruction compared to individual medications.
Paper Details　
Original Abstract of the Article :
The efficacy of bronchodilator therapy was assessed in the long-term management of patients with chronic bronchitis and varying degrees of reversible air-flow obstruction. Twenty-five patients with a mean forced expiratory volume in one second (FEV1) 38.7% predicted received: optimized doses of oral...See full text at original site
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引用元：
https://doi.org/10.1164/arrd.1985.131.5.747

データ提供：米国国立医学図書館（NLM）

Finding the Right Balance: Theophylline, Salbutamol, and Chronic Bronchitis

The desert of chronic bronchitis is a challenging landscape, with patients seeking relief from persistent airway inflammation and obstruction. This study investigates the effectiveness of different bronchodilator therapies in managing chronic bronchitis with reversible airflow obstruction. The researchers compared the effects of theophylline, salbutamol, and a combination of the two, seeking the most effective approach to improving lung function and reducing symptoms.

A Symphony of Bronchodilators

The study found that the combination of theophylline and salbutamol, like a harmonious symphony of bronchodilators, offered significant advantages in controlling symptoms and improving lung function compared to placebo or either drug alone. This underscores the potential of combining different treatment approaches to achieve optimal outcomes in managing chronic bronchitis.

Breathing Easier in the Desert of Chronic Bronchitis

This study provides valuable insights into the management of chronic bronchitis. The combination therapy, like a refreshing oasis in the desert, offers a more effective approach to managing symptoms and improving lung function.

Dr.Camel's Conclusion

This research is a testament to the power of combining different therapeutic approaches in managing chronic bronchitis. The study highlights the benefits of a balanced approach, like finding the right oasis in the desert, to provide optimal care for those struggling with this persistent condition.

Date :
  1. Date Completed 1985-06-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

4003919

DOI: Digital Object Identifier

10.1164/arrd.1985.131.5.747

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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