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Circulatory effects of intravenous and oral acebutolol in acute myocardial infarction.

Author: BaligaG, ClarkeJ, NelsonG, SilkeB, TaylorS H, VermaS P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Acebutolol, a beta-blocker, was studied for its hemodynamic effects in men with acute myocardial infarction. Both intravenous and oral acebutolol reduced blood pressure, heart rate, and cardiac output, confirming its safety in this context.
Paper Details　
Original Abstract of the Article :
The hemodynamic dose-response effects of intravenous (25 and 50 mg) and oral (200 and 400 mg) acebutolol were compared in a randomized between-group study in men within 17 hours of an acute uncomplicated myocardial infarction. Six subjects were evaluated in each of the four groups. After a 1-hour co...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1985.169

データ提供：米国国立医学図書館（NLM）

Acebutolol: A Steady Hand in the Desert of Myocardial Infarction

Myocardial infarction, a heart-stopping event, requires swift and effective treatment to mitigate its devastating consequences. This study investigates the hemodynamic effects of acebutolol, a beta-blocker, in patients experiencing acute myocardial infarction. Researchers carefully evaluated the dose-response effects of acebutolol administered intravenously and orally, comparing its impact on various hemodynamic variables. They found that acebutolol effectively reduced systemic arterial pressure, heart rate, cardiac output, and stroke volume, demonstrating its ability to stabilize the cardiovascular system in the aftermath of a heart attack. This research, much like a steady hand guiding a lost traveler through a sandstorm, highlights the potential of acebutolol as a valuable tool in managing the aftermath of myocardial infarction.

A Stable Course through the Storm of Myocardial Infarction

This research provides valuable insights into the hemodynamic effects of acebutolol in the setting of acute myocardial infarction. Acebutolol, like a skilled navigator guiding a ship through a tempestuous sea, demonstrates its ability to stabilize the cardiovascular system, reducing blood pressure, heart rate, and other key variables. This study offers valuable guidance for clinicians managing patients after myocardial infarction, emphasizing the importance of careful monitoring and adjustments in medication dosage.

A Vital Tool for Cardiovascular Stability

This research underscores the vital role of acebutolol in promoting cardiovascular stability after myocardial infarction. Acebutolol, like a sturdy camel traversing the unforgiving desert, provides a sense of security and stability in the aftermath of a heart attack. This study serves as a reminder that careful medication management is crucial for optimizing recovery from myocardial infarction, minimizing risks and promoting long-term cardiovascular health.

Dr. Camel's Conclusion

This study, my dear readers, is a testament to the power of medication to stabilize the cardiovascular system in the face of a heart attack. Acebutolol, like a reliable oasis in the desert of myocardial infarction, provides a steady hand for managing this critical condition.

Date :
  1. Date Completed 1985-10-11
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

4028620

DOI: Digital Object Identifier

10.1038/clpt.1985.169

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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