Paper Details

  1. Home
  2. Paper Details

Long-term prophylaxis of urinary infections in women: comparative trial of trimethoprim, methenamine hippurate and topical povidone-iodine.

Author: BrumfittW, CooperJ, GarganR A, Hamilton-MillerJ M, SmithG W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 64 patients with frequent urinary tract infections compared three long-term preventative treatments: nightly trimethoprim, methenamine hippurate twice daily, and twice-daily perineal cleansing with povidone-iodine solution. All treatments effectively reduced the number of urinary tract infections compared to the year before treatment. While all treatments were effective, trimethoprim was better tolerated and reduced colonization of E. coli in the periurethral area. However, most breakthrough infections in the trimethoprim group were caused by trimethoprim-resistant bacteria, while this was less common in other groups. This study suggests that trimethoprim may be a good preventative option, but it’s important to be aware of the potential for developing resistant bacteria.
Paper Details　
Original Abstract of the Article :
We randomized 64 patients with a history of recurrent urinary tract infections among 3 regimens of long-term (1 year) prophylactic treatment: 20 were given 100 mg. trimethoprim at night, 25 received 1,000 mg. methenamine hippurate every 12 hours and 19 were asked to cleanse the perineum (especially ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0022-5347(17)51709-7

データ提供：米国国立医学図書館（NLM）

Preventing Urinary Infections in Women: A Comparative Trial of Prophylactic Treatments

Urinary tract infections (UTIs) are a common health concern, particularly for women, often leading to discomfort and recurrent infections. This study investigates the efficacy of different long-term prophylactic treatments for preventing UTIs in women. Imagine a desert oasis, a haven for travelers seeking respite from the harsh conditions. This study explores different approaches to prevent UTIs, like safeguarding this oasis from potential contamination. Researchers randomly assigned women with recurrent UTIs to three different treatment groups, comparing the effectiveness of trimethoprim, methenamine hippurate, and topical povidone-iodine. Their findings revealed that all three treatments were effective in reducing the incidence of symptomatic UTIs, highlighting the potential of these prophylactic approaches in preventing recurring infections.

Safeguarding the Oasis: Prophylactic Treatments for UTIs

This study provides a valuable roadmap for preventing UTIs in women. The researchers, like skilled desert engineers, evaluated the effectiveness of different prophylactic treatments, discovering that each approach offered a significant level of protection against recurrent infections. These findings, like a well-constructed barrier protecting the oasis, offer hope for women struggling with UTIs, providing a path towards a healthier and more comfortable life.

A Personalized Approach: Tailoring UTI Prevention Strategies

This study emphasizes the importance of a personalized approach to UTI prevention. It highlights the need to consider individual factors, such as medication tolerance and susceptibility to specific bacteria, in selecting the most effective prophylactic treatment. Think of it as tailoring a protective barrier for the oasis, ensuring that it's designed to address the unique challenges of each traveler.

Dr.Camel's Conclusion

This study underscores the effectiveness of long-term prophylactic treatments for preventing UTIs in women, offering valuable insights into different approaches and the importance of a personalized strategy.

Date :
  1. Date Completed 1984-01-07
  2. Date Revised 2019-06-21
Further Info :

Pubmed ID

6227756

DOI: Digital Object Identifier

10.1016/s0022-5347(17)51709-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.