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EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.

Author: McClellandG R, RaptopoulosP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Paroxetine, a selective serotonin reuptake inhibitor, significantly altered the EEG in normal volunteers, decreasing delta and theta activity and increasing beta activity. These changes persisted 72 hours after treatment.
Paper Details　
Original Abstract of the Article :
The quantitative electroencephalogram (EEG) and plasma concentration of the antidepressant paroxetine were monitored in five normal volunteers after a single oral dose of 70 mg paroxetine and placebo. Peak plasma concentration occurred 4-6 h post-dose. Placebo had little effect on the EEG but the ef...See full text at original site
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引用元：
https://doi.org/10.1007/BF00428539

データ提供：米国国立医学図書館（NLM）

The Enigmatic Effects of Paroxetine on the Brain

The world of [neuropharmacology] is constantly searching for new ways to understand and treat [mental health] disorders. This study explores the [effects of paroxetine] on the [brain] by monitoring both [EEG activity] and [plasma concentration] in healthy volunteers. The authors discovered that [paroxetine] significantly altered [brain wave patterns], reducing [delta and theta activity] while increasing [beta activity]. These changes were still evident [72 hours] after treatment, suggesting a [long-lasting impact] on the brain.

Unveiling Paroxetine's Brain Activity

The study's results show that [paroxetine] significantly alters [brain activity], [decreasing] the slower [delta and theta waves] and [increasing] the faster [beta waves]. These findings provide a better understanding of how [paroxetine] works in the brain.

Understanding the Impact of Antidepressants

This research sheds light on the [potential effects] of [antidepressants] on the [brain]. It emphasizes the importance of understanding the [mechanisms] by which these drugs work, including their impact on [brain wave patterns]. While this study focuses on [paroxetine], the findings have implications for the use of other [antidepressants] as well.

Dr.Camel's Conclusion

The brain is a complex and mysterious landscape, and [paroxetine] offers us a glimpse into its workings. This study provides valuable insights into how [antidepressants] affect the brain, reminding us that even subtle changes in [brain activity] can have significant effects.

Date :
  1. Date Completed 1984-12-12
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6238338

DOI: Digital Object Identifier

10.1007/BF00428539

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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