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Acebutolol therapy for ventricular arrhythmia. A randomized placebo-controlled double-blind multicenter study.

Author: AronowW S, ChandraratnaP A, De SoyzaN, LadduA R, ShapiroW, ThompsonC H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Acebutolol significantly reduced ventricular ectopy in 60 patients with a mean of at least 30 ventricular premature complexes per hour. Over 50% of the patients experienced a greater than 70% reduction in VPCs/hour. Side effects were transient and Acebutolol was discontinued in one patient due to side effects.
Paper Details　
Original Abstract of the Article :
The safety and efficacy of acebutolol in suppressing ventricular ectopy was evaluated in 60 males (average 59 years) using 24-hour Holter recordings and a double-blind, randomized, crossover protocol. Acebutolol, 200 mg and 400 mg thrice daily, was compared with placebo. Only patients who had a mean...See full text at original site
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引用元：
https://doi.org/10.1161/01.cir.65.6.1129

データ提供：米国国立医学図書館（NLM）

Acebutolol: A Promising Therapy for Ventricular Arrhythmia

Ventricular arrhythmia, an irregular heartbeat originating from the lower chambers of the heart, can be a serious health concern. This study explores the efficacy and safety of acebutolol, a beta-blocker medication, in suppressing ventricular ectopy, a type of arrhythmia characterized by premature heartbeats originating in the ventricles. The study involved 60 male patients with frequent ventricular premature complexes (VPCs) and utilized a double-blind, randomized, crossover protocol to compare acebutolol at two different doses (200 mg and 400 mg thrice daily) with a placebo.

Acebutolol: A Beacon of Hope for Ventricular Arrhythmia

The results showed a significant reduction in VPCs per hour in over 50% of the patients during acebutolol therapy. This reduction was dose-dependent, with both doses of acebutolol effectively suppressing VPCs and ventricular tachycardia episodes. Furthermore, acebutolol significantly reduced resting heart rate and blood pressure, indicating a positive impact on overall cardiovascular function.

Acebutolol: A Safe and Effective Treatment Option

Acebutolol emerged as a safe and effective treatment option for ventricular arrhythmia, with most side effects being transient and well-tolerated. These findings suggest that acebutolol could play a valuable role in managing this common arrhythmia, potentially improving the lives of many patients.

Dr.Camel's Conclusion

This study is like discovering a rare desert flower that blooms even in the harshest conditions. Acebutolol, a beta-blocker, proves to be a safe and effective treatment for ventricular arrhythmia, a condition that can feel like a relentless sandstorm in the heart. The study's findings are a beacon of hope for patients, offering a potential oasis of relief from the discomfort and risks of this arrhythmia.

Date :
  1. Date Completed 1982-07-19
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

7042111

DOI: Digital Object Identifier

10.1161/01.cir.65.6.1129

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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