Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.

Author: MellstrandT, SvedmyrK, SvedmyrN

Paper Details 
Original Abstract of the Article :
The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1398-9995.1982.tb01884.x

データ提供:米国国立医学図書館(NLM)

Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation

This research delves into the world of [pharmacology and respiratory medicine], exploring the bioavailability and bronchodilating effects of different theophylline formulations in asthmatic patients. The study, a [randomized, double-blind, cross-over study], compared the pharmacokinetic profiles and therapeutic effects of various theophylline tablets, including microcrystallinic theophylline, choline theophyllinate, and theophyllaminopropanol. It revealed that all formulations exhibited similar bioavailability and effectiveness in improving lung function. Furthermore, the study found that theophylline, when combined with inhaled terbutaline, exhibited enhanced bronchodilation, suggesting a potential synergy between these medications.

Theophylline: A Synergistic Approach to Asthma Management

The study demonstrates that different theophylline formulations exhibit comparable efficacy in managing asthma symptoms. Notably, the combination of theophylline and inhaled terbutaline resulted in improved bronchodilation, hinting at a synergistic effect. This finding opens avenues for optimizing asthma treatment by combining different medications to achieve enhanced therapeutic outcomes. It's like two camels working together to carry a heavy load, each contributing to the overall success of the journey.

Breathing Easier with Theophylline

Asthma sufferers can potentially benefit from this research, as it highlights the effectiveness of various theophylline formulations in managing their condition. The study also suggests that combining theophylline with inhaled terbutaline could lead to improved lung function and easier breathing. This discovery could empower asthma patients to better manage their condition and enjoy a better quality of life.

Dr.Camel's Conclusion

This study is a breath of fresh air for asthma patients! It demonstrates that theophylline offers a reliable and effective treatment option, and that combining it with inhaled terbutaline can potentially enhance its bronchodilating effects. This research provides valuable insights for optimizing asthma management and improving the lives of individuals living with this chronic condition.
Date :
  1. Date Completed 1982-12-16
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

7137520

DOI: Digital Object Identifier

10.1111/j.1398-9995.1982.tb01884.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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