Comparison of molindone and tranylcypromine in the treatment of refractory depression.

Author: DennisJ L, KellamsJ J, MilsteinV, SmallJ G

Paper Details 
Original Abstract of the Article :
A single-blind parallel study of 20 treatment-resistant hospitalized depressed patients showed that 10-30 mg/day molindone was more effective and less toxic than 20-30 mg tranylcypromine. Molindone-treated patients responded during the first week with particular improvement in anxiety symptoms and a...See full text at original site
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引用元:
https://doi.org/10.1002/j.1552-4604.1981.tb01780.x

データ提供:米国国立医学図書館(NLM)

Molindone vs. Tranylcypromine: A Battle of Refractory Depression

The depths of depression can be a daunting and isolating experience. This study delves into the world of refractory depression, a form of depression that doesn't respond well to standard treatments. The researchers conducted a single-blind parallel study to compare the efficacy and safety of two medications: molindone and tranylcypromine.

Molindone Emerges as a Promising Solution

The study revealed that molindone, at a dosage of 10-30 mg/day, was more effective and less toxic than tranylcypromine in treating refractory depression. Molindone-treated patients experienced a quicker response, particularly with anxiety symptoms and agitation. This finding is like finding a hidden spring in the desert: a source of relief amidst the harsh realities of refractory depression. The study also found that extrapyramidal symptoms, a common side effect of molindone, were effectively managed with amantadine.

Hope for Refractory Depression Patients

This research offers a glimmer of hope for those struggling with refractory depression. The findings suggest that molindone, in low dosages, might be an effective treatment option, providing a more rapid response with fewer side effects. It's a reminder that even in the most challenging of landscapes, there's often a path to recovery. It's essential to work closely with healthcare professionals to find the most effective treatment for your individual needs.

Dr. Camel's Conclusion

This study offers valuable insights into the treatment of refractory depression, highlighting the potential benefits of molindone. It's a reminder that even in the vast and complex world of mental health, there's always hope for a better tomorrow. As a wise camel navigates the desert, so too must we carefully choose our path towards mental well-being, seeking guidance from experts along the way.
Date :
  1. Date Completed 1981-11-22
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

7276229

DOI: Digital Object Identifier

10.1002/j.1552-4604.1981.tb01780.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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