Bronchodilator effects of low doses of oral theophylline and terbutaline in asthmatic subjects.

Author: CalvareseB, DeutschR I, LeeY E, SimmonsM, TashkinD P, WangerJ

Paper Details 
Original Abstract of the Article :
The acute pulmonary and cardiovascular effects of single doses of theophylline 130 mg and terbutaline 2.5 mg administered alone and in combination were compared with placebo over a period of seven hours in 16 stable asthmatic subjects. Terbutaline 2.5 mg produced significant bronchodilatation that p...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/7416558

データ提供:米国国立医学図書館(NLM)

A Breath of Relief: Exploring Bronchodilator Combinations for Asthma

The search for effective and safe asthma treatments continues to be a vital area of research. This study delves into the potential benefits of combining low doses of theophylline and terbutaline, two commonly used bronchodilators, for asthma management. The researchers conducted a study on 16 stable asthmatic subjects, comparing the effects of single doses of theophylline (130 mg) and terbutaline (2.5 mg) alone and in combination with a placebo over a seven-hour period. While terbutaline effectively produced bronchodilation, theophylline alone had minimal impact. The combination of theophylline and terbutaline did not provide additional bronchodilation beyond that achieved with terbutaline alone.

A Twist in the Tale: Theophylline's Role in Asthma

This study demonstrates the limitations of using low doses of theophylline in combination with terbutaline for asthma management. While terbutaline effectively opened the airways, theophylline did not provide any additional benefit in this context.

Managing Asthma: A Multifaceted Approach

Asthma management involves a variety of approaches, including medications, lifestyle adjustments, and environmental controls. This research underscores the importance of individualizing treatment plans based on each patient's specific needs and responses to medication. It's essential to work closely with a healthcare provider to find the most effective and safe treatment strategy.

Dr.Camel's Conclusion

Imagine a thirsty camel in the desert searching for a refreshing oasis. This research explores whether combining theophylline and terbutaline for asthma is like finding a double oasis. It seems, in this case, the double oasis is not quite as effective as a single oasis.

Date :
  1. Date Completed 1980-11-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7416558

DOI: Digital Object Identifier

7416558

SNS
PICO Info
in preparation
Languages

English

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