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Comparison of effect on psychomotor performance of single doses of propranolol and acebutolol.

Author: BroadhurstA D

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Propranolol significantly prolonged complex reaction time in healthy volunteers compared to placebo or acebutolol. Acebutolol did not affect complex reaction time. Two volunteers reported mild dizziness after propranolol, while no side effects were reported after acebutolol.
Paper Details　
Original Abstract of the Article :
Propranolol has recently been shown to produce some impairment of psychomotor performance in human volunteers. This beta-blocking compound, however, is lipophilic and readily penetrates the blood-brain barrier to gain access to the central nervous system. Acebutolol has a lower lipid solubility. A s...See full text at original site
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引用元：
https://doi.org/10.1185/03007998009116512

データ提供：米国国立医学図書館（NLM）

Propranolol and Psychomotor Performance: A Race Against Time

In the world of beta-blockers, propranolol has been known to put a bit of a damper on psychomotor performance. This research investigates the effects of propranolol, a lipophilic drug that easily crosses the blood-brain barrier, compared to acebutolol, a less lipid-soluble beta-blocker. Using a complex reaction time technique, researchers found that propranolol significantly slowed down reaction times compared to placebo or acebutolol. The study also noted mild feelings of 'muzziness' in some individuals after taking propranolol. Acebutolol, however, didn't seem to affect reaction times or cause any notable side effects. This research provides valuable insights into the potential impact of beta-blockers on psychomotor performance, highlighting the importance of individual patient considerations.

Propranolol's Effect on Psychomotor Performance: A Cautionary Tale

While propranolol is often used to treat conditions like high blood pressure, this study suggests that its effects on psychomotor performance should be considered, especially for individuals who engage in activities requiring quick reactions. The study's findings highlight the importance of careful monitoring and personalized treatment approaches when prescribing propranolol, particularly for patients whose work or lifestyle involves tasks that require quick reflexes.

A Reminder to Pace Yourself: Navigating the Side Effects of Beta-Blockers

This study underscores the importance of understanding the potential side effects of medications, especially those that act on the brain. While beta-blockers can be lifesavers for many conditions, their impact on mental function should not be overlooked. The research provides a valuable reminder to listen to your body and communicate any concerns about potential side effects with your doctor, ensuring that your treatment plan is tailored to your individual needs.

Dr.Camel's Conclusion

Propranolol, while effective for many conditions, may impact psychomotor performance. This study highlights the importance of personalized treatment plans and careful monitoring, especially for individuals whose activities require quick reflexes. Just like a camel navigating a desert, it's important to be aware of potential hazards and adjust accordingly, ensuring a safe and successful journey.

Date :
  1. Date Completed 1981-01-16
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

7428410

DOI: Digital Object Identifier

10.1185/03007998009116512

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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