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Comparison of fluticasone propionate and sodium cromoglycate for the treatment of childhood asthma (an open parallel group study).

Author: PriceJ F, WellerP H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Fluticasone propionate (FP) was found to be more effective than sodium cromoglycate (SCG) in treating mild-to-moderate asthma in children aged 4-12 years. FP significantly improved peak expiratory flow rate (PEFR), the number of symptom-free days and nights, compared to SCG. However, there was no significant difference in forced expiratory volume in one second (FEV1) or the use of relief medication between the two groups.
Paper Details　
Original Abstract of the Article :
Inhaled corticosteroids are highly effective in the treatment of asthma at all ages and their use in younger children is increasing. As concerns exist about the long-term systemic side-effects of high dose inhaled corticosteroids, current guidelines continue to recommend sodium cromoglycate (SCG) as...See full text at original site
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引用元：
https://doi.org/10.1016/0954-6111(95)90009-8

データ提供：米国国立医学図書館（NLM）

Comparing Fluticasone Propionate and Sodium Cromoglycate for Childhood Asthma

This research investigates the effectiveness of two common treatments for childhood asthma: inhaled corticosteroids and sodium cromoglycate (SCG). The study, conducted in a randomized, open, multi-center, parallel group design, compared the efficacy and safety of fluticasone propionate (FP) and SCG in 225 asthmatic children aged 4-12 years. The researchers found that low-dose FP was more effective than SCG in improving asthma symptoms and reducing medication use, highlighting the potential benefits of this newer inhaled corticosteroid for treating childhood asthma.

Fluticasone Propionate Shows Promise for Childhood Asthma

The study demonstrated that low-dose FP was superior to SCG in improving key asthma parameters, including peak expiratory flow rate (PEFR) and symptom-free days and nights. These findings suggest that FP may be a more effective treatment option for young children with mild-to-moderate asthma. However, the study highlights the need for longer-term safety studies before changing current recommendations for inhaled corticosteroid therapy.

Navigating the Landscape of Asthma Treatment

The study underscores the importance of considering the individual needs of children with asthma when choosing treatment options. The research suggests that FP may be a valuable addition to the arsenal of asthma treatments, but further research is necessary to confirm its long-term safety and efficacy. It's like navigating a desert landscape, where different paths offer different challenges and rewards. Choosing the right path for each individual is crucial for achieving the best outcome.

Dr. Camel's Conclusion

This research highlights the importance of ongoing research into effective and safe treatments for childhood asthma. Just as a wise camel navigates the desert, understanding the options and choosing the best path for each individual is essential for managing this chronic condition.

Date :
  1. Date Completed 1995-09-11
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

7638372

DOI: Digital Object Identifier

10.1016/0954-6111(95)90009-8

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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