Side Effects of cromolyn oral inhalation: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major Research Findings

Cromolyn sodium is a medication that is often used to prevent asthma attacks. Many studies have shown that cromolyn sodium is effective in preventing asthma attacks. 8 showed that cromolyn sodium can inhibit the bronchial response to exercise, inhalation of cold air, and to antigens. It can also help control asthma and reduce the need for bronchodilators. 10 showed that cromolyn sodium is at least as effective as theophylline in controlling asthmatic symptoms in children aged 1-6 years. Cromolyn sodium is also a safer drug than theophylline, with fewer side effects.

Reasons for Side Effects

Cromolyn sodium works by preventing the release of substances that cause inflammation in the airways. Side effects are usually caused by irritation of the airways or by an allergic reaction to the drug.

Common Side Effects

Dry Mouth

Cromolyn sodium inhalers can cause dry mouth. 8 reported that cromolyn sodium can cause a bad taste in the mouth.

Cough

Cromolyn sodium inhalers can cause coughing. 7 indicated that cromolyn sodium can cause coughing due to irritation of the airways.

Worsening of Asthma

In rare cases, cromolyn sodium inhalers can worsen asthma symptoms. 8 reported that cromolyn sodium can improve asthma control; however, it is possible that some patients may experience worsening symptoms.

Side Effects Treatment

Dry Mouth

If you experience dry mouth, you can gargle with water after using the inhaler. You can also drink plenty of fluids.

Cough

If you experience coughing, you can reduce the amount of inhaler you use, or talk to your doctor.

Worsening of Asthma

If your asthma symptoms worsen, talk to your doctor right away.

Comparison Between Studies

Similarities

Many studies have shown that cromolyn sodium is an effective drug for preventing asthma attacks. It has also been shown to be a safer drug than other asthma medications, with fewer side effects.

Differences

There are differences in the effectiveness and side effects of cromolyn sodium depending on the study. This is due to differences in the patients who participated in the study and the study methodology.

Things to Keep in Mind When Applying This Information to Real Life

Cromolyn sodium is a safe and effective drug for preventing asthma attacks. However, it is important to be aware of the potential side effects. Dry mouth and coughing are two of the most common side effects. When using the inhaler, follow your doctor's instructions carefully and talk to your doctor if you experience any side effects.

Limitations of Current Research

There is still insufficient research on the long-term safety of cromolyn sodium inhalers. The effectiveness of cromolyn sodium inhalers may not be applicable to all asthma patients.

Future Research Directions

Further research is needed on the long-term safety of cromolyn sodium inhalers, identifying patients who can benefit from the drug, and discovering new side effects.

Conclusion

Cromolyn sodium inhalers are effective drugs for preventing asthma attacks. However, there is a possibility of side effects. Therefore, be sure to follow your doctor's instructions carefully and talk to your doctor if you experience any side effects.

Literature analysis of 14 papers
Positive Content
13
Neutral Content
1
Negative Content
0
Article Type
5
1
1
2
14
2.

Examining the Characteristics of Colchicine-Induced Myelosuppression in Clinical Cases: A Systematic Review.

Author: SimBernice L, SimBeatrice Z, TunbridgeMatthew, LiewDavid F L, RobinsonPhilip C

Cardiovascular treatment
Inflammation treatment
Myelosuppression

Colchicine, a drug used for various conditions, can cause myelosuppression, necessitating careful monitoring of blood cell counts in patients receiving colchicine.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing.

Author: BisgaardHans, AllenDavid, MilanowskiJanusz, KalevIlia, WillitsLisa, DaviesPatricia

Reduced wheeze symptoms
No significant growth impact

This study compared the safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in treating recurrent wheeze in children aged 1 to 3 years. The results showed that FP had no significant effect on growth and was well-tolerated. FP was more efficacious than SCG, with fewer symptom exacerbations and greater symptom-free days.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Cost-effective pharmacotherapy for inhalant allergic rhinitis.

Author: HadleyJames A

Allergic rhinitis treatment

This article discusses the role of the otolaryngologist in the management of respiratory allergies. It highlights the importance of second-generation antihistamines in reducing side effects and improving tolerance compared to first-generation antihistamines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

[Therapeutic and toxic theophylline levels in asthma attacks--is there a need for additional theophylline?].

Author: ZeidmanA, GardynJ, FradinZ, FinkG, MittelmanM

Asthma treatment
Theophylline toxicity

This study examined theophylline serum levels in patients with bronchial asthma presenting to the emergency room with an acute attack. The majority of patients had therapeutic theophylline levels, suggesting that intravenous theophylline may not be necessary in these cases and could even lead to toxicity.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Hebrew

6.

Comparison of fluticasone propionate and sodium cromoglycate for the treatment of childhood asthma (an open parallel group study).

Author: PriceJ F, WellerP H

Asthma treatment
Improved lung function
Side effects

Fluticasone propionate (FP) was found to be more effective than sodium cromoglycate (SCG) in treating mild-to-moderate asthma in children aged 4-12 years. FP significantly improved peak expiratory flow rate (PEFR), the number of symptom-free days and nights, compared to SCG. However, there was no significant difference in forced expiratory volume in one second (FEV1) or the use of relief medication between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Role of inhalation therapy in the management of childhood asthma].

Author: GrimfeldA, JustJ, BodartE

Asthma treatment
Childhood asthma

Inhaled drugs are effective in treating childhood asthma, but the appropriate device depends on the child's age. Inhaled B2 agonists are effective during attacks, while inhaled corticosteroids are used for long-term prevention.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

8.

[Review of North American studies on nedocromil sodium].

Author: BouletL P

Asthma control
Asthma prevention
Bad taste

Nedocromil sodium is a new prophylactic antiasthmatic medication with anti-inflammatory properties superior to sodium cromoglycate. It can be used to replace theophyllines and reduce the need for bronchodilators.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

9.

[Parental knowledge about their asthmatic children].

Author: Bernard-BonninA C, PelletierH, Allard-DansereauC, ChabotG, RobertM, MassonP, MaheuxB, RobitailleN

Improved asthma knowledge
Lack of knowledge about medication
Need for more information

A questionnaire about asthma was given to parents of 171 children. The study found that mothers with higher education levels had better knowledge of asthma symptoms and triggers. Parents who were satisfied with previous asthma education had a better understanding of asthma attack signs and the side effects of asthma medications.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : French

10.

Comparison of nebulised sodium cromoglycate and oral theophylline in controlling symptoms of chronic asthma in pre-school children: a double blind study.

Author: NewthC J, NewthC V, TurnerJ A

Controls asthmatic symptoms
Less use of supplementary medication
Theophylline side effects

This study compared the efficacy of nebulized sodium cromoglycate and oral theophylline in 26 children with chronic asthma. Sodium cromoglycate was at least as effective as theophylline in controlling asthmatic symptoms. Theophylline was associated with numerous adverse side effects, while sodium cromoglycate was not.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Evaluation of ketotifen (HC20-511) in bronchial asthma.

Author: PatersonJ W, YellinR H, TaralaR A

Asthma treatment
Lethargy
Sedation

Ketotifen and sodium cromoglycate were both effective in treating outpatient asthma. Some patients responded better to ketotifen, while others responded better to cromoglycate. Both medications caused sedation and lethargy in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

[An experimental and clinical study of the effect of ketotifen in the treatment of extrinsic bronchial asthma (author's transl)].

Author: HartmannV, MagnussenH, HolleJ P

Asthma treatment
Side effects

Ketotifen, a new anti-allergic drug, was found to be effective in treating extrinsic bronchial asthma. It significantly increased the amount of allergen needed to provoke a bronchospasm compared to cromoglycate. Ketotifen also improved asthmatic symptoms more than clemastine, with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

14.

Evaluation of a new aerosolized steroid for asthma therapy: beclomethasone dipropionate (Vanceril inhaler).

Author: BallinJ C

Asthma control
Safer alternative
Candida infections

Beclomethasone dipropionate, an esterified derivative of betamethasone, can be given in small doses in aerosol form to patients with severe asthma.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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