Paper Details

  1. Home
  2. Paper Details

Biopharmaceutic characteristics of a new extended-release theophylline formulation (Uni-Dur).

Author: AffrimeM B, BrannanM D, GroenH, HempeniusJ, JonkmanJ H, NomeirA A, OosterhuisB, PeetersP A, RadwanskiE

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Maintaining stable plasma concentrations of theophylline is crucial for optimal airway function and minimizing adverse effects.
Paper Details　
Original Abstract of the Article :
There is a close relationship between improvement in airway function and the plasma concentration of theophylline, as well as between rapidly rising plasma theophylline concentrations and increased frequency of undesired effects. Development of pharmaceutical formulations and prescribed dosage inter...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/7648380

データ提供：米国国立医学図書館（NLM）

Stabilizing Theophylline Concentrations: A New Extended-Release Formulation

This research focuses on theophylline, a medication used to treat asthma and other respiratory conditions. The study explores the development of a new extended-release theophylline formulation, Uni-Dur, aimed at providing more stable plasma concentrations of the drug. The authors emphasize the importance of maintaining consistent theophylline levels in the blood, as fluctuations can lead to both ineffective treatment and increased side effects.

Ensuring Effective and Safe Theophylline Treatment

The authors explain the rationale behind developing a new extended-release formulation. By providing a more stable and predictable theophylline concentration, Uni-Dur is designed to enhance the effectiveness of treatment while reducing the risk of adverse events. The study suggests that this new formulation could lead to improvements in patient outcomes.

A Steady Stream of Benefits: Considerations for Theophylline Use

This research highlights the importance of pharmaceutical formulations in optimizing drug delivery and achieving optimal therapeutic outcomes. It underscores the need for innovative drug delivery systems that ensure consistent and predictable drug concentrations in the body, particularly for medications with a narrow therapeutic window.

Dr.Camel's Conclusion

This research is like a camel caravan carefully navigating a desert path. Maintaining consistent theophylline levels is like ensuring the caravan's water supply – too much, and you risk dehydration; too little, and you risk exhaustion. The new extended-release formulation of Uni-Dur is like finding a new water source in the desert – a steady and reliable supply that can sustain the journey towards better health.
Date :
  1. Date Completed 1995-09-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7648380

DOI: Digital Object Identifier

7648380

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.