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The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results.

Author: DjukanovićR, FinnertyJ P, HolgateS T, LeeC, MaddenJ, WilsonS

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Theophylline, at doses lower than those required for bronchodilation, may contribute to asthma control by reducing suppressor/cytotoxic T-cells and cytokines involved in allergic mucosal responses.
Paper Details　
Original Abstract of the Article :
Theophylline, a nonspecific phosphodiesterase inhibitor, has only recently been reconsidered as a potential anti-inflammatory drug. Its ability to inhibit late asthmatic responses has pointed to possible inhibition of mechanisms regulating the influx and activity of inflammatory cells into the airwa...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/7656958

データ提供：米国国立医学図書館（NLM）

Theophylline's Anti-Inflammatory Effects in Asthma

The world of asthma research is always bustling with exciting discoveries, and this particular study delves into the fascinating world of theophylline, a drug previously known for its bronchodilator effects, and its potential as an anti-inflammatory agent. Using a combination of biopsy results and controlled trials, researchers explored how theophylline impacts the inflammatory process in asthmatic airways. They discovered that theophylline can effectively reduce the number of T-cells, a type of white blood cell involved in the immune response, that infiltrate the airways, potentially preventing the development of asthma symptoms. In other words, theophylline might be like a desert oasis, calming down the immune system's overzealous response in the airways.

Theophylline's Potential Role in Asthma Control

This research suggests that theophylline could be a valuable weapon in the fight against asthma. By targeting the inflammatory process, theophylline might help to control asthma symptoms and improve quality of life for individuals with asthma. In a double-blind, placebo-controlled trial, theophylline-treated patients experienced a significant decrease in epithelial CD8+ T-cells and a reduction in the inflammatory cytokines, interleukin 4 and 5 (IL-4 and IL-5), compared to the placebo group. This is exciting news for individuals with asthma who are looking for alternative or additional treatment options.

Theophylline: An Oasis in the Desert of Asthma

It's crucial to remember that this is just one study, and more research is needed to confirm these findings and explore the long-term effects of theophylline on asthma control. However, this study offers a glimmer of hope for individuals with asthma, highlighting the potential of theophylline to alleviate their symptoms and improve their overall well-being. Like a refreshing oasis in the midst of the desert, theophylline may offer relief and a chance for individuals with asthma to breathe easier and live more comfortably.

Dr.Camel's Conclusion

This study suggests that theophylline might be a valuable weapon in the fight against asthma, offering a refreshing oasis for individuals seeking relief from this debilitating condition. Further research is needed to confirm these findings, but the potential for theophylline to improve the lives of individuals with asthma is exciting and encouraging.

Date :
  1. Date Completed 1995-09-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7656958

DOI: Digital Object Identifier

7656958

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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