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Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.

Author: BarnesP J, ChungK F, DominguezM, KidneyJ, RoseM, TaylorP M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Theophylline withdrawal can lead to increased asthma symptoms and decreased lung function. It is associated with changes in peripheral leukocyte populations.
Paper Details　
Original Abstract of the Article :
Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is increasing evidence that it may have immunomodulatory effects. We have investigated the effects of theophylline withdrawal under placebo control in 27 asthmatic patients (25 to 70...See full text at original site
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引用元：
https://doi.org/10.1164/ajrccm.151.6.7767539

データ提供：米国国立医学図書館（NLM）

Theophylline: Beyond Bronchodilation

This research delves into the world of respiratory medicine, specifically focusing on theophylline, a medication commonly used to treat asthma. The study investigates the immunomodulatory effects of theophylline, exploring its potential impact on immune cell populations in both the peripheral blood and airways. The researchers aim to provide evidence for theophylline's immunomodulatory properties, adding to our understanding of its therapeutic mechanisms in asthma.

Theophylline: A Multifaceted Therapeutic Agent

The study provides compelling evidence for theophylline's immunomodulatory effects beyond its bronchodilatory properties. The researchers observed significant changes in peripheral blood monocyte and activated T-lymphocyte populations after theophylline withdrawal, suggesting that theophylline plays a role in regulating immune responses in asthma. These findings support the notion that theophylline's therapeutic benefits extend beyond simple bronchodilation, potentially influencing the underlying inflammatory processes in asthma.

Understanding the Immune Landscape of Asthma

This research offers valuable insights into the complex interplay between theophylline and the immune system in asthma. It underscores the importance of understanding the immunomodulatory effects of medications, particularly in chronic inflammatory conditions like asthma. By embracing a comprehensive understanding of the immune landscape of asthma, we can develop more effective and targeted therapeutic strategies.

Dr.Camel's Conclusion

This research expands our understanding of theophylline's therapeutic properties, revealing its potential to modulate immune responses in asthma. Just as a camel adapts to its environment to thrive in the desert, we must continue to explore the diverse roles of medications in human health. This research is a testament to the ongoing evolution of our knowledge in respiratory medicine and the continuous pursuit of more effective treatments for asthma.

Date :
  1. Date Completed 1995-06-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7767539

DOI: Digital Object Identifier

10.1164/ajrccm.151.6.7767539

SNS
PICO Info
in preparation
Languages

English

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