Pharmacokinetics and additional anti-ischaemic effectiveness of amlodipine, a once-daily calcium antagonist, during acute and long-term therapy of stable angina pectoris in patients pre-treated with a beta-blocker.

Author: BeyerleA, LehmannG, ReinigerG, RudolphW

Paper Details 
Original Abstract of the Article :
Amlodipine 10 mg was evaluated for additional anti-ischaemic and anti-anginal efficacy in 14 patients pre-treated with a beta-blocker who had documented coronary artery disease, stable angina pectoris, and > or = 2 mm of exercise-induced ST segment depression. For 2 days the patients received open-l...See full text at original site
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引用元:
https://doi.org/10.1093/eurheartj/14.11.1531

データ提供:米国国立医学図書館(NLM)

Amlodipine's Anti-Ischemic Efficacy: A Double-Blind Study

This research explores the world of cardiology, specifically investigating the effectiveness of amlodipine, a calcium antagonist, as an additional anti-ischemic agent in patients already taking beta-blockers for stable angina pectoris. It's like a grand exploration, with scientists carefully assessing the interplay of two different medications. Using a randomized, placebo-controlled, cross-over and double-blind protocol, the researchers, akin to meticulous archaeologists, unearthed fascinating findings. Their study showed that amlodipine, in combination with beta-blockers, significantly decreased ST segment depression and increased ischemia-free workload capacity in patients with stable angina pectoris. It's as if amlodipine, like a skilled navigator, guides the heart towards a smoother path, reducing the strain and improving its capacity.

Amlodipine: A Powerful Addition to Angina Treatment

The study demonstrates that amlodipine, when added to beta-blocker therapy, significantly enhances anti-ischemic efficacy in patients with stable angina pectoris. This finding suggests that amlodipine can be a valuable tool for managing angina, offering a more comprehensive approach to improving cardiovascular health.

A More Stable Heartbeat

This research suggests that amlodipine can provide a more stable heartbeat and potentially reduce the frequency of angina attacks in patients with stable angina pectoris. It's as if amlodipine provides a calming presence, soothing the heart and reducing the risk of painful episodes.

Dr.Camel's Conclusion

Amlodipine, like a desert oasis offering respite from the heat, proves to be a powerful addition to beta-blocker therapy for patients with stable angina pectoris, improving their heart health and providing them with a more stable and comfortable life.

Date :
  1. Date Completed 1994-03-04
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

7905413

DOI: Digital Object Identifier

10.1093/eurheartj/14.11.1531

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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