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[Differences in hemodynamic effects of the cardioselective beta-adrenoblocker acebutolol and non-selective beta-adrenoblocker propranolol in long-term antihypertensive therapy].

Author: BelolipetskaiaV G, DudaS G, LermanO V, MalyshevaN V, ManoshkinaE M, MetelitsaV I, OstrovskaiaT P, PiotrovskiĭV K, RumiantsevD O, ShastunR S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol, a cardioselective beta-adrenoblocker, was found to be as effective as propranolol in reducing blood pressure, with fewer side effects such as bradycardia.
Paper Details　
Original Abstract of the Article :
The cardioselective beta-adrenoblocker acebutolol used as a course therapy for 12 weeks was found to be a highly beneficial antihypertensive agent. The antihypertensive effect of the agent given in doses of 400-800 mg/day was as pronounced and prolonged as that of propranolol, 80-160 mg/day, though ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7933789

データ提供：米国国立医学図書館（NLM）

Acebutolol: A Cardioselective Beta-Blocker for Hypertension

The realm of hypertension, or high blood pressure, is vast and complex, with numerous medications vying for a place in the treatment arsenal. This research focused on the effectiveness of a cardioselective beta-blocker called acebutolol, comparing it to the non-selective beta-blocker propranolol. Both drugs are used to manage high blood pressure, but acebutolol is designed to target specific receptors in the heart, while propranolol acts more broadly.

Acebutolol's Antihypertensive Effect

Acebutolol proved to be an effective antihypertensive agent, achieving a similar level of blood pressure control as propranolol. Interestingly, the researchers observed that acebutolol's antihypertensive effect was more pronounced after a few weeks of treatment, whereas propranolol's effect was evident more immediately. This suggests that acebutolol's effectiveness may gradually increase over time.

Acebutolol's Antihypertensive Effect

Acebutolol's selective action on heart receptors makes it a promising option for managing high blood pressure. This study highlights the potential benefits of acebutolol, especially for those who may be sensitive to the broader effects of non-selective beta-blockers.

Dr.Camel's Conclusion

This study shines a light on acebutolol, a drug that could be likened to a more focused camel caravan navigating the desert of hypertension. Its selective action on heart receptors makes it a valuable tool for managing high blood pressure.
Date :
  1. Date Completed 1994-11-16
  2. Date Revised 2017-03-10
Further Info :

Pubmed ID

7933789

DOI: Digital Object Identifier

7933789

SNS
PICO Info
in preparation
Languages

Russian

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