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Relationships between pharmacokinetics and nonpulmonary pharmacodynamic effects of theophylline.

Author: HenryJ A, HuseyinT S, MintonN A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined the relationship between theophylline concentration and its effects on various bodily functions. The results indicate that theophylline's effects on electrolyte balance and blood pressure are delayed, likely due to intracellular mechanisms.
Paper Details　
Original Abstract of the Article :
Concentration-effect relationships between oral theophylline and its nonpulmonary pharmacodynamic effects were examined in a double-blind, randomized, two-way crossover study in which 10 healthy subjects received a single dose of 500 mg ordinary-release theophylline or placebo. Mean plasma theophyll...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1994.188

データ提供：米国国立医学図書館（NLM）

Theophylline: A Balancing Act Between Pharmacokinetics and Pharmacodynamics

The study delves into the intricate relationship between theophylline's pharmacokinetics (how the body processes the drug) and its pharmacodynamic effects (how the drug affects the body). The authors investigated the nonpulmonary effects of theophylline, examining its impact on various physiological parameters, such as blood pressure, potassium, and magnesium levels. Their findings highlight the complex interplay between pharmacokinetic and pharmacodynamic factors, emphasizing the importance of understanding these interactions for optimizing therapeutic outcomes.

Delay in the Desert: Understanding the Time Lag

The study observed a delay in the onset of theophylline's nonpulmonary pharmacodynamic effects, suggesting that the drug's actions are mediated by intracellular processes. This delay, known as negative hysteresis, highlights the need to consider not just the concentration of the drug in the bloodstream but also the time it takes for the drug to exert its effects. The researchers emphasize the importance of recognizing these discrepancies between pharmacokinetic and pharmacodynamic profiles to accurately assess the duration of action of a drug.

Navigating the Pharmacokinetic Desert: A Journey Through the Body

This study serves as a reminder that the human body is a complex and dynamic system. Understanding the intricate interplay between pharmacokinetics and pharmacodynamics is essential for navigating the desert of drug therapy. This research highlights the importance of considering individual patient characteristics and the nuances of drug metabolism when making treatment decisions.

Dr. Camel's Conclusion

This study showcases the complexities of drug therapy and the importance of understanding the interplay between pharmacokinetics and pharmacodynamics. Recognizing the potential for delays in drug action and the impact of intracellular processes is crucial for maximizing therapeutic benefits and minimizing potential side effects. As researchers continue to unravel the mysteries of drug metabolism and action, we can expect even more precise and personalized approaches to drug therapy in the future.

Date :
  1. Date Completed 1995-01-18
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

7995005

DOI: Digital Object Identifier

10.1038/clpt.1994.188

SNS
PICO Info
in preparation
Languages

English

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