Cholesterol reduction and death from non-coronary causes: evidence from randomised controlled trials.

Author: MacMahonS

Paper Details 
Original Abstract of the Article :
An overview of randomised trials of cholesterol reduction (26 trials, 50,000 patients, net cholesterol reduction approximately 10%) provides clear evidence of a reduction in the incidence of coronary heart disease (CHD) after just a few years of treatment. Overall, the observed reduction in CHD deat...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1111/j.1445-5994.1994.tb04447.x

データ提供:米国国立医学図書館(NLM)

Cholesterol Reduction: A Tale of Two Deaths

The field of [cardiology] is constantly seeking ways to improve [cardiovascular health] and reduce the risk of [coronary heart disease (CHD)]. This study examines the impact of [cholesterol reduction] therapy on mortality from both CHD and non-coronary causes. The researchers conducted a comprehensive overview of 26 randomized controlled trials, involving over 50,000 patients, to assess the long-term effects of cholesterol-lowering interventions.

Navigating the Sands of Mortality: A Two-Sided Story

The study found that cholesterol reduction therapy effectively decreased the incidence of CHD, a result consistent with previous findings. However, the researchers also observed a [small excess] of deaths from non-coronary causes, such as cancer and trauma, among patients receiving cholesterol-lowering treatment. This finding is like navigating a desert landscape where different types of terrain pose unique dangers.

A Balancing Act: Weighing the Benefits and Risks

The study's findings highlight the need for careful consideration when evaluating the potential benefits and risks of cholesterol reduction therapy. While it offers a significant reduction in CHD mortality, the potential for increased non-coronary mortality requires further investigation. This is like navigating a desert oasis – while it offers respite and rejuvenation, it also requires vigilance against potential hazards lurking in the surrounding environment.

Dr.Camel's Conclusion

This research offers a nuanced perspective on the effects of cholesterol reduction therapy, highlighting the complex interplay between its benefits and potential risks. The study underscores the importance of ongoing research to further explore the long-term impact of these interventions on overall mortality, ensuring that we navigate the desert of cardiovascular health with a balanced and informed approach.

Date :
  1. Date Completed 1994-07-14
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

8002850

DOI: Digital Object Identifier

10.1111/j.1445-5994.1994.tb04447.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.