Paper Details

  1. Home
  2. Paper Details

Neurobehavioral effects of phenytoin and carbamazepine in patients recovering from brain trauma: a comparative study.

Author: GoldfaderP R, GouldingP M, Holterman-HommesP, SmithK R, WeiF, WildermanD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that both phenytoin and carbamazepine may have negative effects on cognitive performance, particularly on tasks involving motor and speed components. While practice effects may account for some improvement when patients stopped taking these drugs, the overall effects were small and of limited clinical significance.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the effects of prophylactic anticonvulsant use of phenytoin and carbamazepine on the cognitive and emotional status of the patient after brain injury. DESIGN: Double-blind, placebo-controlled study with assessments before and after withdrawal from drug treatment. SETTING: Pat...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1001/archneur.1994.00540190029012

データ提供：米国国立医学図書館（NLM）

Navigating the Aftermath of Brain Trauma: Exploring the Neurobehavioral Effects of Anticonvulsants

Brain trauma can leave a lasting impact on cognitive function and emotional well-being. Imagine a desert landscape where a sudden sandstorm has disrupted the delicate balance of the ecosystem. This study delves into the neurobehavioral effects of phenytoin and carbamazepine, two commonly used anticonvulsants, in patients recovering from brain trauma. The researchers are like skilled desert ecologists, seeking to understand how these medications affect the brain's recovery process.

Unveiling the Potential Impact of Anticonvulsants

The study found that both phenytoin and carbamazepine could have negative effects on cognitive performance, particularly on tasks involving motor skills and speed. The researchers also observed significant improvement in some cognitive measures after patients stopped taking the medications. It's like observing how a desert ecosystem adapts to changes in its environment, sometimes experiencing both challenges and resilience.

A Reminder of the Importance of Personalized Care

The study highlights the importance of carefully considering the potential benefits and risks of anticonvulsants for patients with brain trauma. It emphasizes the need for individualized treatment plans and close monitoring to ensure optimal outcomes. It's like finding the right balance between restoring stability and supporting the natural recovery process of a desert ecosystem.

Dr. Camel's Conclusion

This study provides valuable insights into the neurobehavioral effects of anticonvulsants in patients recovering from brain trauma. It underscores the importance of personalized care and close monitoring to optimize outcomes and support the brain's recovery process. It's like navigating a complex desert landscape, being mindful of the potential challenges and seeking to create a path towards healing and restoration.

Date :
  1. Date Completed 1994-07-25
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

8018037

DOI: Digital Object Identifier

10.1001/archneur.1994.00540190029012

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.