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No short-term changes of cognitive performance and mood after single doses of two different lithium retard preparations.

Author: GreilW, KathmannN, KolkA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A single dose of lithium carbonate or lithium sulfate did not cause significant cognitive impairment or mood changes in healthy volunteers within six hours of administration. This suggests that lithium-induced alterations of memory and mood develop gradually and are not immediate effects.
Paper Details　
Original Abstract of the Article :
This double-blind crossover study investigated the effects of single doses of lithium carbonate (36.6 mval), lithium-sulfate (36 mval), and placebo within the first six hours after administration. The subjects were nine healthy volunteers. The target variables were physical complaints, mood, memory,...See full text at original site
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引用元：
https://doi.org/10.1055/s-2007-1014360

データ提供：米国国立医学図書館（NLM）

Lithium's Impact on Cognition: A Double-Blind Exploration

The study delves into the effects of lithium on cognitive function and mood, specifically investigating whether single doses of lithium carbonate or lithium sulfate have immediate effects on cognitive performance and well-being. The researchers conducted a double-blind crossover study, comparing the effects of these lithium preparations to a placebo in nine healthy volunteers. The study aims to understand the time course of lithium's effects on cognitive function, particularly the impact on memory and mood.

Lithium's Subtle Influence: A Gradual Shift in Cognition

The study found no significant impairment of cognitive performance or subjective changes in mood within the first six hours after administering single doses of lithium. This suggests that the cognitive and mood alterations associated with lithium develop over a longer period and are not immediately apparent. The study's findings are like observing a slow and steady shift in the desert landscape, where the effects of lithium are subtle and gradual, taking time to become noticeable.

Navigating the Shifting Sands: Understanding Lithium's Effects

The study's findings emphasize the importance of understanding the time course of lithium's effects on cognitive function. It highlights the need for careful monitoring of patients taking lithium, particularly in the early stages of treatment. This research is like a camel caravan navigating through a desert of unknowns, seeking to understand the nuanced and sometimes delayed effects of lithium on the human mind.

Dr.Camel's Conclusion

This research offers valuable insight into the intricate relationship between lithium and cognitive function. It's like a camel guide leading us through the vast and sometimes perplexing desert of mental health, seeking to understand the complexities of how medications impact our minds. This research serves as a reminder of the importance of careful observation and understanding when it comes to medication and its effects on our cognitive well-being.

Date :
  1. Date Completed 1994-04-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8127927

DOI: Digital Object Identifier

10.1055/s-2007-1014360

SNS
PICO Info
in preparation
Languages

English

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