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A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group.

Author: LenhoffS, LjungmanP, NikoskelainenJ, ParkkaliT, RembergerM, RingdénO, RuutuT, SallerforsB, VindeløvL, VolinL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study of 167 patients with leukemia receiving marrow transplants found that patients treated with busulfan had a higher incidence of veno-occlusive disease of the liver, hemorrhagic cystitis, and transplant-related mortality compared to those treated with total body irradiation (TBI).
Paper Details　
Original Abstract of the Article :
Between October 1988 and December 1992, 167 patients with leukemia receiving marrow transplants from HLA-identical donors and conditioned with cyclophosphamide (120 mg/kg) were randomized to additional treatment with either busulfan (16 mg/kg, n = 88) or total body irradiation (TBI; n = 79). The bus...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8167351

データ提供：米国国立医学図書館（NLM）

Bone Marrow Transplantation: A Tale of Two Conditioning Regimens

Bone marrow transplantation, a life-saving procedure for individuals with leukemia and other blood disorders, involves conditioning the recipient's body to prepare for the transplant. This research compares two conditioning regimens: busulfan and total body irradiation (TBI). The study investigates the efficacy and safety of both regimens, evaluating their impact on transplant-related outcomes.

Busulfan vs. TBI: Weighing the Options

The study found that patients treated with busulfan experienced higher rates of veno-occlusive disease of the liver, hemorrhagic cystitis, and transplant-related mortality, particularly in those with advanced disease. TBI, on the other hand, was associated with better outcomes in patients with advanced disease. Imagine choosing a route across a desert – each path presents unique challenges and risks. This research provides valuable insights into the choices facing clinicians when selecting a conditioning regimen for bone marrow transplantation.

Navigating the Complexities of Bone Marrow Transplantation

This research underscores the importance of carefully considering the risks and benefits of each conditioning regimen for bone marrow transplantation. It emphasizes the need for personalized treatment decisions, taking into account the patient's individual characteristics and the severity of their disease. Like navigating a desert with different routes, each patient's journey requires a tailored approach.

Dr.Camel's Conclusion

This research on bone marrow transplantation reminds me of the ancient trade routes across the desert – each path presenting its own challenges and rewards. It highlights the importance of careful consideration when choosing a conditioning regimen, emphasizing the need for a personalized approach that balances potential risks and benefits. This research is a testament to the ongoing quest for safer and more effective treatment options in the field of bone marrow transplantation.

Date :
  1. Date Completed 1994-06-01
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

8167351

DOI: Digital Object Identifier

S0006-4971(20)70051-0

SNS
PICO Info
in preparation
Languages

English

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