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A study comparing paroxetine placebo and imipramine in depressed patients.

Author: CohnJ B, DunbarG C, FabreL F, FeighnerJ P, FieveR R, MendelsJ, ShrivastavaR K

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Paroxetine and imipramine were both effective for depression, but paroxetine may have a greater and earlier effect on anxiety. Paroxetine side effects were similar to other serotonin reuptake inhibitors, but different from those of imipramine, with fewer anticholinergic and cardiovascular symptoms and less premature withdrawal.
Paper Details　
Original Abstract of the Article :
These data provide evidence for the antidepressant efficacy of paroxetine. Paroxetine- and imipramine-treated patients were significantly different from placebo-treated patients, but little different to each other, on all depressive outcome measures. However, paroxetine appeared to have a possibly g...See full text at original site
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引用元：
https://doi.org/10.1016/0165-0327(93)90035-i

データ提供：米国国立医学図書館（NLM）

Paroxetine vs. Imipramine vs. Placebo in Treating Depression

This study compares the efficacy of [paroxetine], a selective serotonin reuptake inhibitor (SSRI), with [imipramine], a tricyclic antidepressant, and [placebo] in treating [depressed patients]. The researchers evaluated the antidepressant effects of these medications, focusing on depressive symptoms and anxiety associated with depression.

Paroxetine Shows Promise in Treating Depression and Anxiety

The study demonstrated that both paroxetine and imipramine were significantly more effective than placebo in alleviating depressive symptoms. Paroxetine, however, appeared to have a potentially greater and earlier beneficial effect on anxiety symptoms compared to imipramine. Both active therapies proved effective in treating patients with severe depression.

Navigating the Depressive Landscape with Medication: A Camel's Perspective

This research sheds light on the diverse landscape of antidepressant medications. Just as a camel navigates a desert with varying terrains, finding the right treatment for depression can be a challenging journey. Paroxetine, with its effectiveness in treating both depression and anxiety, offers a potentially valuable option for individuals seeking relief from these debilitating conditions.

Dr. Camel's Conclusion

This study highlights the importance of finding the right medication to navigate the challenging terrain of depression. Just as a camel seeks a reliable source of water in the desert, individuals with depression need a safe and effective medication to alleviate their symptoms. The research suggests that paroxetine, with its potential benefits in treating both depression and anxiety, may be a valuable tool for individuals seeking relief from these debilitating conditions.

Date :
  1. Date Completed 1993-09-22
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8354771

DOI: Digital Object Identifier

10.1016/0165-0327(93)90035-i

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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