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Amlodipine once a day in stable angina: double-blind crossover comparison with placebo.

Author: CheitlinM D, DasS K, DeedwaniaP C, PasternakR C, PoolP E, SinghJ B

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Amlodipine, a dihydropyridine calcium antagonist, has a long half-life and high bioavailability, allowing for once-daily administration. It is effective in treating chronic stable angina and vasospastic angina, with efficacy comparable to beta blockers and other calcium antagonists. Amlodipine has minimal effects on heart rate and contractility and does not cause tolerance.
Paper Details　
Original Abstract of the Article :
Although calcium antagonists form a mainstay of therapy in patients with angina pectoris, the currently available agents have significant limitations. Nifedipine, diltiazem, and verapamil are all high-clearance agents with significant hepatic extraction and rapid clearance, leading to limited and sh...See full text at original site
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引用元：
https://doi.org/10.1002/clc.4960160808

データ提供：米国国立医学図書館（NLM）

Amlodipine: A Long-Lasting Oasis in the Desert of Angina

The world of cardiovascular disease is a vast and unforgiving desert, where the threat of angina, a type of chest pain caused by reduced blood flow to the heart, is a constant concern. This study examines the effectiveness and tolerability of amlodipine, a calcium channel blocker, in the treatment of stable angina. The authors conducted a double-blind crossover trial, akin to a caravan testing two different routes across the desert, comparing amlodipine to placebo. They found that amlodipine, with its long half-life, was effective in reducing angina symptoms and improving overall quality of life, providing a long-lasting oasis of relief for patients. It's as if amlodipine, like a camel that can store water for extended periods, provides a sustained and steady source of relief from the discomfort of angina.

Amlodipine: A Long-Lasting Oasis in the Desert of Angina

This study demonstrates the efficacy of amlodipine in managing stable angina, providing patients with a long-lasting oasis of relief from their symptoms. This finding is particularly encouraging given the long half-life of amlodipine, allowing for once-daily administration, making it a convenient and effective treatment option for patients.

Navigating the Angina Desert

This study underscores the importance of finding the right treatment for angina, just as a camel needs to find the right oasis for its journey. The authors' findings suggest that amlodipine, with its long-lasting effects, may be a valuable tool for managing angina symptoms, providing a more comfortable and manageable experience for patients.

Dr.Camel's Conclusion

Amlodipine emerges as a valuable oasis in the desert of angina, offering patients a long-lasting respite from their symptoms. This study provides compelling evidence for the efficacy and convenience of amlodipine in managing stable angina, a finding that could significantly improve the lives of those living with this cardiovascular condition. It's a reminder that even in the most challenging landscapes, there are often oases of hope and healing waiting to be discovered.

Date :
  1. Date Completed 1993-10-14
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8370191

DOI: Digital Object Identifier

10.1002/clc.4960160808

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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