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Behavioral and cognitive effect of theophylline: a dose-response study.

Author: LernerC A, SteinM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Theophylline is a drug that is used to treat asthma. This study found that theophylline can improve behavior in children with asthma, but that these effects are short-lived and that most children experience no long-term effects on their behavior or cognitive function.
Paper Details　
Original Abstract of the Article :
The behavioral and cognitive effects of theophylline were studied in 14 asymptomatic asthmatic children. A double-blind crossover design was used with two dosage levels. Conners parent ratings suggest behavioral improvement by the second week of treatment, regardless of dosage or order of administra...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8430921

データ提供：米国国立医学図書館（NLM）

Theophylline and Behavior: A Dose-Response Study in Asthmatic Children

This study investigates the behavioral and cognitive effects of theophylline, a medication commonly used to treat asthma, in asthmatic children. The study examined the effects of different dosages of theophylline on a group of children, using a double-blind crossover design. The researchers found that theophylline was associated with behavioral improvement, but no significant effects on cognitive measures were observed.

Theophylline's Behavioral Effects: A Complex Picture

The study indicates that theophylline, while seemingly beneficial for behavior, may not have a significant impact on cognitive function. However, the researchers observed that the behavioral benefits of theophylline primarily occurred during the initial phase of treatment, suggesting that its effects might be transient. This finding highlights the importance of monitoring both behavioral and cognitive changes in children receiving theophylline therapy.

Optimizing Asthma Treatment: A Balanced Approach

The study underscores the need for careful consideration when using theophylline to treat asthma in children. While it may have beneficial effects on behavior, clinicians should be aware of its potential transient effects and monitor for any cognitive changes. A balanced approach to asthma treatment, taking into account the individual needs of each child, is crucial for maximizing therapeutic benefits and minimizing potential risks.

Dr.Camel's Conclusion

This study, like a camel navigating a sandy landscape, reveals a complex relationship between theophylline and the behavior of asthmatic children. While theophylline may provide temporary behavioral benefits, it appears to have no significant impact on cognitive function. This research reminds us that every child is unique, and a personalized approach to asthma treatment is essential for achieving optimal outcomes.

Date :
  1. Date Completed 1993-03-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8430921

DOI: Digital Object Identifier

8430921

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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