A comparison of paroxetine and placebo in depressed outpatients.

Author: ClaghornJ L, DunbarG C, KievA, RickelsK, SmithW T

Paper Details 
Original Abstract of the Article :
To compare the safety and efficacy of paroxetine (n = 167) and placebo (n = 169), data from 4 centres using the same protocol were pooled. A double-blind parallel group design was used, with therapy lasting 6 weeks. Significant differences between paroxetine- and placebo-treated patients were found ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1600-0447.1993.tb03376.x

データ提供:米国国立医学図書館(NLM)

A Double-Blind Study: Paroxetine vs. Placebo for Depression

This research dives deep into the world of [mental health] by comparing the effectiveness of paroxetine, an antidepressant, to a placebo in treating depressed patients. The study employed a [double-blind, parallel group design] with a treatment duration of 6 weeks. The researchers observed significant differences in the efficacy of paroxetine compared to the placebo, as measured by the Hamilton Rating Scale for Depression, as early as week 2. This finding suggests that paroxetine could be a promising treatment option for depression, particularly in the context of its well-tolerated side effects.

Paroxetine Shows Promise in Treating Depression

The study revealed that paroxetine-treated patients demonstrated significant improvements in depression symptoms, indicating its potential as an effective treatment option. Notably, the improvement in sleep quality, a crucial aspect of depression management, was observed as early as 7 days after initiating treatment. The results suggest that paroxetine may offer a faster and more effective path to relief for individuals struggling with depression.

Navigating Side Effects of Depression Medications

While paroxetine exhibited promising efficacy, it is important to acknowledge that it, like other serotonin reuptake inhibitors, can come with side effects. While these side effects were generally well-tolerated, they may necessitate careful monitoring and management by healthcare professionals. Understanding the potential side effects and working closely with your doctor is essential for optimizing the benefits of paroxetine while minimizing any potential risks.

Dr.Camel's Conclusion

This study sheds light on the potential of paroxetine in treating depression, providing a beacon of hope for those seeking relief from this debilitating condition. However, it is crucial to remember that every individual responds differently to medication, and the best approach to treating depression involves a personalized strategy tailored to the specific needs of each patient. Just as a camel navigates the vast and unforgiving desert, finding the right path to recovery requires a delicate balance of scientific evidence and individual needs.

Date :
  1. Date Completed 1993-07-16
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

8517168

DOI: Digital Object Identifier

10.1111/j.1600-0447.1993.tb03376.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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