The influence of perindopril and the diuretic combination amiloride+hydrochlorothiazide on the vessel wall properties of large arteries in hypertensive patients.

Author: BreedJ G, HoeksA P, KoolM J, LustermansF A, RenemanR S, Struyker BoudierH A, Van BortelL M

Paper Details 
Original Abstract of the Article :
To compare the cardiovascular effects of 6 months of treatment with the angiotensin converting enzyme inhibitor perindopril and with the diuretic combination amiloride+hydrochlorothiazide, and to study possible persistence of observed treatment effects after discontinuation of antihypertensive thera...See full text at original site
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引用元:
https://doi.org/10.1097/00004872-199508000-00004

データ提供:米国国立医学図書館(NLM)

Comparing the Effects of Perindopril and Amiloride+Hydrochlorothiazide on Vessel Wall Properties

This research delves into the fascinating world of cardiovascular health, specifically exploring the effects of different medications on blood vessel properties in patients with high blood pressure. Think of this as a comparison between two different types of camels traversing a desert landscape – perindopril, an angiotensin-converting enzyme inhibitor (ACE inhibitor), and the combination of amiloride and hydrochlorothiazide, a diuretic duo. The researchers wanted to see how these medications affected the walls of large arteries over six months, and whether the effects persisted after stopping treatment. They employed a rigorous study design to ensure that the results were accurate and reliable. The team discovered intriguing differences between the two treatment groups, highlighting the importance of individualized care when choosing medications for hypertension.

The Significance of This Research in Hypertension Management

The study's results have significant implications for how we manage hypertension. The discovery of the persistence of treatment effects after discontinuation is particularly promising, suggesting that these medications may have lasting benefits beyond the initial period of use. This knowledge empowers healthcare professionals to make informed decisions about medication choices and treatment duration based on individual patient needs and goals.

Practical Implications for Patients

The study's findings underscore the importance of working closely with your doctor to manage hypertension. They can help you understand the various treatment options available and determine which is best suited for your individual needs. Remember, like a thirsty traveler in a desert, your body needs the right resources to thrive. By understanding the potential long-term benefits of different medications, you can work collaboratively with your healthcare team to make informed choices about your health and wellbeing.

Dr. Camel's Conclusion

This research, like a well-placed oasis in a vast desert, sheds light on the complex relationship between hypertension and medication choices. Understanding the nuances of these medications can help patients make informed decisions about their health, ensuring they are equipped to navigate the challenging landscape of cardiovascular management. Remember, like a wise old camel, patience and perseverance are key to a successful journey through the desert of hypertension.

Date :
  1. Date Completed 1996-02-27
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

8557961

DOI: Digital Object Identifier

10.1097/00004872-199508000-00004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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