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Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.

Author: DrymalskiW, EckhoffP J, EriksonN, GarwoodV, HaireC E, KlassenL W, KleinH, MaloleyP, MooreG F, O'DellJ R, PalmerW, WeesS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Rheumatoid arthritis (RA) is a common condition that causes significant health problems. While single medications like methotrexate are often used, many patients do not respond well to these treatments. Despite limited research, many patients are treated with combinations of medications, even though there is limited evidence for their effectiveness.
Paper Details　
Original Abstract of the Article :
Rheumatoid arthritis is a common disease that causes substantial morbidity and mortality. The responses of patients with rheumatoid arthritis to treatment with a single so-called disease-modifying drug, such as methotrexate, are often suboptimal. Despite limited data, many patients are treated with ...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199605163342002

データ提供：米国国立医学図書館（NLM）

Treating Rheumatoid Arthritis: A Search for Balance in the Desert of Chronic Inflammation

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause significant pain and disability. This research explores the effectiveness of different treatment strategies for RA, specifically comparing the use of methotrexate alone, a combination of sulfasalazine and hydroxychloroquine, and a combination of all three medications. The authors conducted a clinical trial to assess the effectiveness of these approaches, seeking to find the optimal path through the desert of chronic inflammation.

Treatment Strategies for RA: Finding Balance in the Desert

The study found that a combination of methotrexate, sulfasalazine, and hydroxychloroquine may be more effective than single-drug therapy for RA. This discovery is like finding a wellspring in the desert, offering a more comprehensive approach to managing this chronic condition. The authors suggest that a combination of drugs may provide a more balanced and effective treatment strategy for RA, potentially leading to better symptom control and improved quality of life.

Navigating the Desert of RA: Seeking Effective Treatments

This research highlights the importance of individualized treatment strategies for RA. It emphasizes the need to consider a variety of factors when determining the most appropriate treatment plan for each patient. This is like understanding the specific terrain of the desert of RA, choosing the most suitable path to manage the disease effectively. The authors encourage further research to explore the optimal combinations of medications for RA, ultimately seeking to find a path towards improved health and well-being for individuals living with this chronic condition.

Dr.Camel's Conclusion

This research is like a camel caravan navigating the vast desert of rheumatoid arthritis. It offers valuable insights into the effectiveness of different treatment strategies, emphasizing the importance of finding a balanced and personalized approach. By continuing to explore new pathways and innovative treatments, we can equip ourselves with the tools to navigate this challenging terrain and find a path towards better health for individuals living with RA.

Date :
  1. Date Completed 1996-05-30
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

8609945

DOI: Digital Object Identifier

10.1056/NEJM199605163342002

SNS
PICO Info
in preparation
Languages

English

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