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Intranasal apomorphine rescue therapy for parkinsonian "off" periods.

Author: AhlskogJ E, DeweyR B, MaraganoreD M, MatsumotoJ Y

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This open-label study evaluated the efficacy and safety of intranasal apomorphine in 11 patients with levodopa-related motor fluctuations in Parkinson's disease. Intranasal apomorphine was found to be effective in rapidly relieving "off" states, with a similar magnitude of motor improvement compared to levodopa/carbidopa. The most common side effects were nausea and vomiting, effectively managed with trimethobenzamide. Intranasal apomorphine offers a rapid and convenient treatment option for managing "off" states in Parkinson's disease.
Paper Details　
Original Abstract of the Article :
Eleven patients with levodopa-related motor fluctuations were scored before and after intranasal apomorphine monotherapy, and the motor responses were compared with those with levodopa/carbidopa in this openlabel study. Oral trimethobenzamide was used to prevent apomorphine-induced nausea. Three mea...See full text at original site
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引用元：
https://doi.org/10.1097/00002826-199619030-00001

データ提供：米国国立医学図書館（NLM）

Intranasal Apomorphine: A Quick Fix for Parkinson's 'Off' Periods

Living with Parkinson's disease can be challenging, especially during 'off' periods when medication effectiveness wanes. This study explored the use of intranasal apomorphine as a rescue therapy for these 'off' states. The researchers compared its effectiveness to levodopa/carbidopa, a common treatment for Parkinson's. The results showed that intranasal apomorphine provided rapid relief of motor symptoms, comparable to levodopa/carbidopa, with a significantly faster onset of action. It's like having a refreshing oasis in the middle of a long and arduous desert journey, providing much-needed relief and energy.

A New Approach to Managing Parkinson's

Intranasal apomorphine offers a promising new approach to managing 'off' periods in Parkinson's disease. Its ease of administration and rapid onset of action make it a valuable tool for patients seeking immediate relief. The study also highlighted the effectiveness of trimethobenzamide in preventing apomorphine-induced nausea, making this treatment even more appealing to patients.

Easing the Burden of Parkinson's

Intranasal apomorphine offers a potential solution to the challenges posed by 'off' periods in Parkinson's disease. Its ability to provide rapid relief can significantly improve quality of life for individuals struggling with this debilitating condition. Think of it as a refreshing breeze blowing through the hot desert air, bringing temporary respite from the heat and allowing for a renewed sense of energy.

Dr. Camel's Conclusion

This research sheds light on the potential of intranasal apomorphine as a valuable treatment option for managing 'off' periods in Parkinson's disease. Its rapid onset of action and effectiveness in relieving motor symptoms offer a significant improvement in quality of life for patients. As a camel who's traversed countless miles of desert, I know the importance of finding sources of water and respite along the way. Intranasal apomorphine provides such an oasis for individuals living with Parkinson's.

Date :
  1. Date Completed 1996-11-27
  2. Date Revised 2019-09-14
Further Info :

Pubmed ID

8726538

DOI: Digital Object Identifier

10.1097/00002826-199619030-00001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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