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Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine.

Author: ChanC H, ChiuH J, HongC J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Paroxetine was found to be as effective as imipramine in treating depression in Chinese patients, but with fewer anticholinergic adverse effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Paroxetine is a potent inhibitor of serotonin re-uptake. Although it has been widely used as an antidepressant in western countries, its efficacy and side effects in the Chinese are unknown. METHODS: Patients with major depressive episode were recruited from the outpatient clinic and th...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8803304

データ提供：米国国立医学図書館（NLM）

Paroxetine vs. Imipramine for Depression: A Comparative Study in Chinese Patients

This study delves into the complexities of treating depression, comparing the effectiveness and side effects of two commonly prescribed antidepressants, paroxetine and imipramine, in Chinese patients. The researchers conducted a double-blind randomized controlled trial involving 40 patients with major depressive episode, carefully monitoring their symptoms and side effects over a six-week period. It's like comparing two different paths through a desert - one lined with vibrant flowers and the other with prickly cacti.

Paroxetine Shows Promise with Fewer Side Effects

The study found that both paroxetine and imipramine were effective in reducing depression symptoms, but paroxetine had significantly fewer anticholinergic side effects compared to imipramine. This finding is particularly important for Chinese patients, who may be more susceptible to these side effects. The study offers valuable insights for clinicians seeking to choose the most effective and tolerable antidepressant for their Chinese patients.

Making Informed Treatment Decisions

This study underscores the importance of personalized treatment decisions. It reminds us that different medications can have varying effects on different individuals, and that choosing the right medication is crucial for achieving optimal outcomes. We must consider not only the effectiveness of a medication but also its potential side effects and how those side effects might impact a patient's quality of life. It's like choosing the right camel for a journey across the desert - a strong and sturdy camel might not be the best choice for a delicate traveler.

Dr.Camel's Conclusion

This study, like a camel's trek across a vast desert, reveals the importance of carefully considering the individual needs of patients. By understanding the specific effects of different medications, clinicians can make more informed decisions that prioritize patient well-being. Just as a wise camel navigates treacherous terrain with ease, we must find ways to navigate the complex landscape of mental health care with compassion and expertise.

Date :
  1. Date Completed 1996-10-24
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

8803304

DOI: Digital Object Identifier

8803304

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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