Paper Details

  1. Home
  2. Paper Details

Double-blind comparison of the side-effect profiles of daily versus alternate-day dosing schedules in lithium maintenance treatment of manic-depressive disorder.

Author: AggernaesH, BjørumN, DavidsenK, JensenH V, MellerupE T, PlengeP, ToftegaardL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the side-effect profiles of daily and alternate-day lithium carbonate dosing schedules in manic-depressive patients. There was no significant difference in side effects between the two dosing schedules.
Paper Details　
Original Abstract of the Article :
The side-effect profiles of daily vs. alternate-day lithium carbonate dosing schedule were compared in a double-blind study of 50 manic-depressive patients. Following a 3-month period on daily lithium maintenance treatment the patients were randomly allocated to daily or alternate-day lithium dosing...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0165-0327(95)00052-6

データ提供：米国国立医学図書館（NLM）

Lithium Dosing Schedules: A Double-Blind Comparison of Side Effects

This study delves into the world of lithium treatment for manic-depressive disorder, investigating the side-effect profiles of different dosing schedules. The researchers conducted a double-blind study comparing daily and alternate-day dosing schedules in 50 patients, aiming to determine if extending the interval between lithium doses could minimize side effects. Their findings offer insights into the potential impact of dosing frequency on the tolerability of lithium therapy.

Minimizing the Desert of Side Effects: Navigating Lithium Dosing

The study found no significant difference in side-effect profiles between the daily and alternate-day lithium dosing schedules. While there was a trend suggesting slightly fewer side effects with alternate-day dosing, this difference was not statistically significant. This suggests that both dosing schedules are equally effective in managing manic-depressive disorder, with similar tolerability profiles. This research provides valuable information for clinicians seeking to optimize lithium therapy for their patients.

A Balanced Approach to Lithium Therapy: Finding the Right Path

This research is like a camel caravan navigating the desert of lithium therapy, exploring different dosing strategies to find the most effective and well-tolerated approach. While alternate-day dosing might offer a slight advantage in minimizing some side effects, the study found no significant overall difference in tolerability between the two schedules. This underscores the importance of individualized treatment plans, considering each patient's unique needs and response to medication.

Dr. Camel's Conclusion

This study reminds us that navigating the desert of psychiatric treatment can be a delicate balancing act. It underscores the importance of individualizing treatment plans, considering patient factors and carefully monitoring response to medication. This research offers valuable insights for clinicians seeking to optimize lithium therapy for patients with manic-depressive disorder.

Date :
  1. Date Completed 1996-10-29
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

8821311

DOI: Digital Object Identifier

10.1016/0165-0327(95)00052-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.