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Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya.

Author: JaokoW G, MuchemiG, OguyaF O

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Praziquantel was well-tolerated with mild and transient side effects.
Paper Details　
Original Abstract of the Article :
Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8898462

データ提供：米国国立医学図書館（NLM）

Praziquantel: A Powerful Weapon against Schistosoma mansoni, but with Side Effects

Schistosomiasis, a parasitic disease caused by Schistosoma worms, affects millions of people worldwide. Praziquantel is the mainstay treatment for schistosomiasis, effectively eliminating the worms and preventing further infection. This study investigated the side effects of praziquantel in school children infected with Schistosoma mansoni in Kibwezi, Kenya. The researchers compared the side effects observed in children treated with praziquantel to those in a control group who received a placebo.

Praziquantel: Effective, but with Some Side Effects

The study found that praziquantel was highly effective in treating Schistosoma mansoni infection, but it also caused some side effects. The most common side effects were abdominal pain, headache, and nausea. These side effects were generally mild and transient, and did not require any specific interventions. The researchers also observed a correlation between the intensity of infection (measured as eggs per gram of feces) and the frequency of side effects, suggesting that individuals with heavier infections might experience more side effects.

Navigating the Treatment Landscape of Schistosomiasis

This study highlights the importance of understanding the potential side effects of praziquantel, particularly in populations with high rates of schistosomiasis. While praziquantel is an effective and generally safe treatment, it's crucial to be aware of potential side effects and to monitor patients closely during and after treatment. A collaborative approach between healthcare providers and patients is essential for managing schistosomiasis effectively.

Dr.Camel's Conclusion

This research, like a well-mapped trail across a vast desert, helps us navigate the treatment landscape of schistosomiasis. It reminds us that even the most effective treatments can come with side effects. Understanding these side effects and managing them effectively is crucial for optimizing patient care and minimizing the impact of this debilitating disease. Our journey continues, with a commitment to finding new and innovative ways to combat schistosomiasis and improve the lives of those affected by this parasitic infection.

Date :
  1. Date Completed 1996-12-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8898462

DOI: Digital Object Identifier

8898462

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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