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Comparison of phenobarbitone, phenytoin with sodium valproate: randomized, double-blind study.

Author: BanuK, RatnamR S, ThilothammalN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Phenobarbitone, phenytoin, and sodium valproate were equally effective in controlling generalized tonic-clonic convulsions. However, sodium valproate had the fewest side effects, followed by phenobarbitone.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the efficacy and side effects of phenobarbitone (PB), phenytoin (PHT) and sodium valproate (SVP) in controlling generalized tonic-clonic convulsions (GTC). DESIGN: Randomized, double blind clinical trial. SETTING: Out-Patients in a tertiary care hospital. PATIENTS: 151 child...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8979563

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Anticonvulsant Medications: Phenobarbitone, Phenytoin, and Sodium Valproate

[Generalized tonic-clonic convulsions (GTC)] are a common type of seizure that can have a significant impact on quality of life. This study compares the efficacy and side effects of three widely used anticonvulsant medications: [phenobarbitone (PB), phenytoin (PHT), and sodium valproate (SVP)]. The researchers conducted a [randomized, double-blind clinical trial] involving 151 children with GTC, assessing the effectiveness of each medication in controlling seizures and monitoring for adverse events. This study aims to provide a comprehensive comparison of these medications, allowing clinicians to make informed decisions about treatment options based on efficacy, safety, and cost-effectiveness.

Navigating the Desert of Epilepsy: A Comparative Study of Anticonvulsant Medications

This study offers a valuable roadmap for navigating the complex world of [anticonvulsant medications]. The researchers have conducted a comprehensive comparison of [PB, PHT, and SVP], providing clinicians with valuable insights into their efficacy, safety, and cost-effectiveness. It’s like having a guidebook to help navigate the vast and sometimes treacherous desert of epilepsy treatment.

Finding the Right Path: Choosing the Best Anticonvulsant Medication

This research provides valuable insights for individuals struggling with [GTC]. By comparing the efficacy and side effects of [PB, PHT, and SVP], the study empowers clinicians to make informed decisions about treatment options, offering a more personalized approach to managing seizures. It’s like finding a hidden oasis of knowledge in the desert of epilepsy treatment, providing the tools to make informed decisions about the best course of action.

Dr.Camel's Conclusion

This study offers a comprehensive comparison of [PB, PHT, and SVP], providing valuable insights for clinicians seeking to manage [GTC]. The research highlights the importance of individualizing treatment based on factors such as efficacy, safety, and cost-effectiveness. It’s like discovering a hidden oasis of knowledge in the desert of epilepsy treatment, offering a roadmap to a brighter future for patients living with seizures.

Date :
  1. Date Completed 1997-02-05
  2. Date Revised 2022-11-29
Further Info :

Pubmed ID

8979563

DOI: Digital Object Identifier

8979563

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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