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Effects of inflammation and treatment on bone turnover and bone mass in polymyalgia rheumatica.

Author: CorrigallV, DasguptaB, DolanA L, LiF, MackintoshC, MonizC, PanayiG S, ToddP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the impact of both systemic inflammation and corticosteroid therapy on bone loss in patients with polymyalgia rheumatica (PMR), which requires corticosteroid treatment.
Paper Details　
Original Abstract of the Article :
Polymyalgia rheumatica (PMR) has an abrupt onset of inflammatory symptoms, making it a useful model for studying the effects of inflammation in bone. PMR requires corticosteroid treatment, which may itself have a detrimental effect on bone. This study used serially measured biochemical markers of bo...See full text at original site
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引用元：
https://doi.org/10.1002/art.1780401115

データ提供：米国国立医学図書館（NLM）

The Impact of Inflammation on Bone in Polymyalgia Rheumatica

Polymyalgia rheumatica (PMR), a condition characterized by widespread muscle pain and stiffness, can be like a desert sandstorm—a sudden and intense onslaught of discomfort. This research investigates the effects of inflammation and corticosteroid treatment on bone metabolism in patients with PMR. The study examines the interplay between inflammation and corticosteroid therapy, two key factors that can influence bone health.

Inflammation and Corticosteroids: A Double-Edged Sword for Bone

The study reveals the complex relationship between inflammation, corticosteroid treatment, and bone loss in PMR. The researchers found that both inflammation and corticosteroid therapy can contribute to bone loss in patients with PMR. This finding underscores the importance of carefully managing both inflammation and corticosteroid use to minimize the risk of bone complications.

Protecting Bone Health in Polymyalgia Rheumatica

This research, a beacon in the vast desert of bone health research, emphasizes the importance of a multi-faceted approach to managing PMR. Patients with PMR require careful monitoring and treatment to minimize the risk of bone complications associated with both inflammation and corticosteroid therapy. Early intervention and appropriate management strategies are crucial for preserving bone health in these individuals.

Dr.Camel's Conclusion

This research, like a desert oasis, offers valuable insights into the complex relationship between inflammation, corticosteroid therapy, and bone health in patients with PMR. The study highlights the importance of managing both inflammation and corticosteroid use to protect bone health in these individuals. It's a reminder that even in the face of challenging medical conditions, there are opportunities to improve patient outcomes through careful management and personalized care.

Date :
  1. Date Completed 1997-12-02
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

9365092

DOI: Digital Object Identifier

10.1002/art.1780401115

SNS
PICO Info
in preparation
Languages

English

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