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Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women.

Author: AndersonP W, FarmerM, KullerL H, LawrenceJ B, PaulS, ShahA S, WalshB W, WildR A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Raloxifene significantly lowers LDL-C, fibrinogen, and lipoprotein(a) in postmenopausal women, and increases HDL2-C without raising triglycerides. These effects are similar to HRT but differ in specific markers.
Paper Details　
Original Abstract of the Article :
CONTEXT: Raloxifene is a selective estrogen receptor modulator that has estrogen-agonistic effects on bone and estrogen-antagonistic effects on breast and uterus. OBJECTIVE: To identify the effects of raloxifene on markers of cardiovascular risk in postmenopausal women, and to compare them with tho...See full text at original site
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引用元：
https://doi.org/10.1001/jama.279.18.1445

データ提供：米国国立医学図書館（NLM）

Raloxifene: A New Oasis in the Desert of Postmenopausal Health

Navigating the challenges of postmenopausal health can feel like traversing a vast, unforgiving desert. This research investigates the potential of raloxifene, a selective estrogen receptor modulator, to mitigate the risks associated with this transition. The study focuses on the effects of raloxifene on markers of cardiovascular risk, comparing its impact to that of hormone replacement therapy (HRT).

Exploring the Effects of Raloxifene

The study, like a desert explorer charting the landscape of cardiovascular health, examines the effects of raloxifene on lipid levels and coagulation parameters. The researchers meticulously analyze the data, comparing the effects of raloxifene to those of HRT and placebo, seeking to understand the potential benefits and risks of this medication.

Navigating the Sands of Cardiovascular Health

The study's findings suggest that raloxifene may offer a promising alternative to HRT for managing cardiovascular risk in postmenopausal women. The research highlights the potential benefits of raloxifene in reducing LDL-C and fibrinogen levels while increasing HDL2-C, offering a positive outlook for heart health.

Dr.Camel's Conclusion

This research, like a desert oasis providing respite from the challenges of menopause, offers a promising new avenue for managing cardiovascular risk. The potential benefits of raloxifene, combined with its favorable side effect profile, warrant further investigation and could pave the way for improved health outcomes for postmenopausal women.
Date :
  1. Date Completed 1998-05-28
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

9600478

DOI: Digital Object Identifier

10.1001/jama.279.18.1445

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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