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Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome.

Author: BallP, BreierA, BuchananR W, CarpenterW T, KirkpatrickB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effectiveness of clozapine for treating both positive and negative symptoms of schizophrenia, including those with and without the deficit syndrome. The researchers also looked at the long-term effects of clozapine on various aspects of the illness, including social and occupational functioning, and quality of life.
Paper Details　
Original Abstract of the Article :
In a preliminary report, the authors observed that clozapine was superior to haloperidol in the treatment of positive and negative symptoms in stable outpatients with schizophrenia. In this final report, they examine the effects of clozapine on positive and negative symptoms in patients with and wit...See full text at original site
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引用元：
https://doi.org/10.1176/ajp.155.6.751

データ提供：米国国立医学図書館（NLM）

Clozapine: A Potential Oasis in the Desert of Schizophrenia

Schizophrenia, a complex and debilitating mental illness, can significantly impact an individual's life. Finding effective treatments for this condition can be challenging, often requiring careful evaluation and tailoring of therapies to meet individual needs. This research investigates the efficacy of clozapine, an atypical antipsychotic, in treating schizophrenia, specifically focusing on its effects on positive and negative symptoms.

The researchers evaluated the effects of clozapine in patients with schizophrenia, both those with and without the deficit syndrome, a subtype characterized by persistent negative symptoms. The results showed that clozapine was superior to haloperidol, a typical antipsychotic, in reducing both positive and negative symptoms in patients with schizophrenia. Furthermore, the researchers found that clozapine's effects on symptoms were sustained over time, suggesting its potential long-term benefits.

A Beacon of Hope for Schizophrenia Treatment: The Promise of Clozapine

This research provides valuable insights into the potential benefits of clozapine in treating schizophrenia. The findings suggest that clozapine can effectively address both positive and negative symptoms, offering a promising therapeutic option for patients with this complex condition.

Navigating the Sands of Schizophrenia Treatment: A Personalized Approach

This research highlights the importance of personalized approaches to schizophrenia treatment. While clozapine has shown promising results, it's essential to carefully evaluate each patient's individual needs and response to medication. Just as a wise traveler in the desert adapts their strategy to the changing landscape, healthcare professionals should tailor their approach to meet the unique needs of each individual with schizophrenia.

Dr.Camel's Conclusion

This research offers a glimmer of hope for individuals living with schizophrenia. Clozapine, an atypical antipsychotic, has shown promising results in reducing both positive and negative symptoms, suggesting a potential path toward improved well-being. However, it's crucial to approach schizophrenia treatment with a personalized approach, considering the individual needs and responses of each patient.

Date :
  1. Date Completed 1998-06-18
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

9619146

DOI: Digital Object Identifier

10.1176/ajp.155.6.751

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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