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Interaction between timolol eyedrops and oral nicardipine or oral diltiazem in healthy Japanese subjects.

Author: KotegawaT, NakamuraK, NakanoS, NakatsukaK, TsutsumiK, YatsukaY I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Timolol, a topical glaucoma medication, can have adverse cardiovascular effects. This study investigated the pharmacodynamic interactions between timolol and two calcium channel blockers, nicardipine and diltiazem.
Paper Details　
Original Abstract of the Article :
Timolol is widely used for the topical therapy of glaucoma. Adverse cardiovascular effects include slowing of the heart rate and weakening of myocardial contractility. We investigated pharmacodynamic interactions with respect to cardiovascular and ocular responses between timolol ophthalmic solution...See full text at original site
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引用元：
https://doi.org/10.1007/s002280050436

データ提供：米国国立医学図書館（NLM）

Timolol Eyedrops and Oral Calcium Channel Blockers: A Cautionary Tale

This study explores the potential for [pharmacodynamic interactions] between [timolol eyedrops], a medication commonly used to treat [glaucoma], and [oral calcium channel blockers], a class of drugs used to treat [high blood pressure and other cardiovascular conditions]. The authors investigated the effects of combining these medications in healthy Japanese subjects, seeking to understand the potential for [adverse cardiovascular effects] and [ocular responses].

Timolol and Calcium Channel Blockers: A Potential for Interaction

The study found evidence of [pharmacodynamic interactions] between timolol and both [nicardipine] and [diltiazem], two commonly used calcium channel blockers. The findings highlight the potential for [additive cardiovascular effects] when these medications are combined, emphasizing the importance of [carefully monitoring patients] and [considering potential drug interactions].

Timolol and Calcium Channel Blockers: A Reminder of Drug Interactions

This research serves as a reminder of the importance of [being aware of potential drug interactions], especially when combining medications that affect the [cardiovascular system]. The study underscores the need for [thorough patient evaluation] and [appropriate medication management] to prevent adverse outcomes.

Dr.Camel's Conclusion

This study is a reminder that even seemingly simple medications can interact in unexpected ways. The authors' investigation of the interaction between timolol eyedrops and oral calcium channel blockers highlights the importance of being vigilant about potential drug interactions, especially when combining medications that affect the cardiovascular system. It's a reminder that [medical knowledge is constantly evolving], and we must remain attentive to [potential risks and benefits] associated with medication use to ensure the safety and well-being of our patients.

Date :
  1. Date Completed 1998-08-12
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

9626919

DOI: Digital Object Identifier

10.1007/s002280050436

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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