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Acute and chronic effects of lithium chloride on physiological and psychological measures in normals.

Author: DaltonJ, KarniolI G, LaderM H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Lithium chloride was found to decrease subjective well-being, skin conductance fluctuations, and increase plasma calcium in an acute experiment. In a chronic experiment, lithium caused subjective impairment, increased EEG slow waves, and a decrease in long-term memory.
Paper Details　
Original Abstract of the Article :
In the acute experiment six healthy volunteers were given orally two doses of lithium chloride, 16 and 32 mmol, and placebo sodium chloride 32 mmol in a double-blind standardized procedure, with a 1-week interval between treatments. Compared to sodium, lithium produced a decrease in subjective well-...See full text at original site
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引用元：
https://doi.org/10.1007/BF00426753

データ提供：米国国立医学図書館（NLM）

Lithium: A Journey Through the Desert of Mood and Memory

Imagine a desert landscape where your mood and memory are constantly shifting. This study investigates the effects of lithium, a mood-stabilizing medication, on physiological and psychological measures in healthy volunteers. The authors conducted two studies, one acute and one chronic, administering lithium chloride to six volunteers in each study. The acute study found that lithium produced a decrease in subjective well-being and skin conductance fluctuations, suggesting potential effects on mood and arousal. The chronic study found that lithium produced feelings of subjective impairment, an increase in EEG slow waves, a deficit in long-term memory, and an increase in plasma magnesium concentrations, suggesting potential effects on cognitive function and memory.

Lithium: A Complex Journey Through the Desert of the Mind

The study's findings highlight the complex effects of lithium on both mood and cognitive function. While lithium is an effective treatment for mood disorders, it's important to be aware of its potential effects on cognitive function and memory. This research emphasizes the need for careful monitoring and individualization of treatment to minimize potential side effects.

Navigating the Desert of Mental Health: A Guide for Patients

If you are taking lithium or other mood-stabilizing medications, it's essential to communicate openly with your healthcare provider about any changes in your mood or cognitive function. Early detection and intervention can help minimize potential side effects and ensure that you receive appropriate care. Remember, managing mental health conditions requires a collaborative approach, and open communication with your healthcare professional is key.

Dr.Camel's Conclusion

This research sheds light on the complex effects of lithium on both mood and cognitive function. While lithium can be an effective treatment for mood disorders, it's crucial to be aware of its potential impact on memory and other cognitive functions. This research emphasizes the need for careful monitoring and individualized treatment approaches to maximize the benefits and minimize the risks of lithium therapy.

Date :
  1. Date Completed 1978-09-15
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

97711

DOI: Digital Object Identifier

10.1007/BF00426753

SNS
PICO Info
in preparation
Languages

English

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