Effective treatment of allergy: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

It is widely believed that for allergic rhinitis and asthma, avoidance of specific triggers can improve symptom control. While many children with asthma or rhinitis are sensitized to airborne allergens, primary care diagnostic and management decisions are often made without a detailed history of the allergic triggers or allergy testing. Thus, treatment decisions are empirical and allergen avoidance advice is either not given or, if given, not tailored to the child's sensitivities. 18

Oral immunotherapy is a promising treatment option for food allergies, including peanut allergy. However, there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

A new therapeutic approach for food allergy treatment is specific oral tolerance induction (SOTI). 6

Immunotherapy is a promising treatment for allergies, particularly for pollen allergies. 2

Sublingual immunotherapy (SLIT) is a promising treatment option for allergic rhinitis. 8

Venom immunotherapy (VIT) has proven efficacy in preventing recurrent anaphylactic reactions in patients with Hymenoptera allergy and allows patients to discontinue carrying an EpiPen. 4

Allergen-specific immunotherapy (SIT) is a specific treatment option when allergen avoidance is problematic. 15

Treatment Summary

Oral immunotherapy is a promising treatment for peanut allergy. 14

Immunotherapy is a promising treatment for allergies. 2

Sublingual immunotherapy (SLIT) is a promising treatment option for allergic rhinitis. 8

Venom immunotherapy (VIT) has proven efficacy in preventing recurrent anaphylactic reactions in patients with Hymenoptera allergy. 4

Allergen-specific immunotherapy (SIT) is a specific treatment option when allergen avoidance is problematic. 15

Benefits and Risks

Benefits Summary

Oral immunotherapy is a promising treatment for peanut allergy. 14

Immunotherapy is a promising treatment for allergies. 2

Sublingual immunotherapy (SLIT) is a promising treatment option for allergic rhinitis. 8

Venom immunotherapy (VIT) has proven efficacy in preventing recurrent anaphylactic reactions in patients with Hymenoptera allergy. 4

Allergen-specific immunotherapy (SIT) is a specific treatment option when allergen avoidance is problematic. 15

Risks Summary

Oral immunotherapy is a promising treatment for peanut allergy but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Specific oral tolerance induction (SOTI) is a promising treatment option for food allergy. 6

Comparison Across Studies

Commonalities

Oral immunotherapy is a promising treatment for allergic conditions. 14 , 19 , 6 , 21 , 12 , 5 , 22

Immunotherapy is a promising treatment for allergies. 2

Sublingual immunotherapy (SLIT) is a promising treatment option for allergic rhinitis. 8

Venom immunotherapy (VIT) has proven efficacy in preventing recurrent anaphylactic reactions in patients with Hymenoptera allergy. 4

Allergen-specific immunotherapy (SIT) is a specific treatment option when allergen avoidance is problematic. 15

Differences

Oral immunotherapy is a promising treatment for peanut allergy but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Specific oral tolerance induction (SOTI) is a promising treatment option for food allergy. 6

Consistency and Contradictions in Results

Oral immunotherapy is a promising treatment for allergic conditions, but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Considerations for Real-World Application

Oral immunotherapy is a promising treatment for peanut allergy. 14

Immunotherapy is a promising treatment for allergies. 2

Sublingual immunotherapy (SLIT) is a promising treatment option for allergic rhinitis. 8

Venom immunotherapy (VIT) has proven efficacy in preventing recurrent anaphylactic reactions in patients with Hymenoptera allergy. 4

Allergen-specific immunotherapy (SIT) is a specific treatment option when allergen avoidance is problematic. 15

Limitations of Current Research

Oral immunotherapy is a promising treatment for allergic conditions, but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Specific oral tolerance induction (SOTI) is a promising treatment option for food allergy. 6

Future Research Directions

Oral immunotherapy is a promising treatment for allergic conditions, but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Specific oral tolerance induction (SOTI) is a promising treatment option for food allergy. 6

Conclusion

Oral immunotherapy is a promising treatment for allergic conditions, but there are challenges such as the loss of desensitization effect after treatment discontinuation and the frequent reversibility of desensitization. 19

Specific oral tolerance induction (SOTI) is a promising treatment option for food allergy. 6

Treatment List

Oral immunotherapy, Sublingual immunotherapy, Specific oral tolerance induction (SOTI)

Literature analysis of 25 papers
Positive Content
24
Neutral Content
0
Negative Content
1
Article Type
18
4
6
6
25
1.

Food allergy in children: results of a standardized protocol for oral desensitization.

Author: PatriarcaG, SchiavinoD, NuceraE, SchincoG, MilaniA, GasbarriniG B

Improved food allergy treatment

This paper proposes a standardized treatment program for food allergies in children, using oral desensitization. The authors note that food allergies in children are a challenging issue, particularly when the food is essential for growth. Existing research on desensitization treatments is limited and inconsistent. This new protocol aims to provide a more structured approach to helping children with food allergies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome.

Author: GehlharK, SchlaakM, BeckerW, BufeA

Symptom reduction

Allergen immunotherapy was evaluated in grass pollen-allergic children. No change in IgE levels was observed, but symptom scores were significantly reduced in the treated group. While allergen-specific IgG1, IgG2 and IgG4 levels increased, the ratio of IgG4 to IgG1 correlated most significantly with symptom scores.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract.

Author: EnriqueErnesto, PinedaFernando, MalekTamim, BartraJoan, BasagañaMaría, TellaRaquel, CastellóJosé Vicente, AlonsoRosario, de MateoJosé Antonio, Cerdá-TriasTeresa, San Miguel-MoncínMaría del Mar, MonzónSusana, GarcíaMaría, PalaciosRicardo, Cisteró-BahímaAnna

Hazelnut allergy treatment
Increased tolerance to hazelnut
Systemic reactions

Sublingual immunotherapy with a standardized hazelnut extract was effective in increasing tolerance to hazelnut in patients allergic to hazelnut. The mean hazelnut quantity provoking objective symptoms increased from 2.29 g to 11.56 g (P=.02) in the active group versus 3.49 g to 4.14 g (placebo). This treatment was well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Analysis of the burden of treatment in patients receiving an EpiPen for yellow jacket anaphylaxis.

Author: Oude ElberinkJoanne N G, van der HeideS, GuyattGordon H, DuboisAnthony E J

Allergy treatment

The study discussed the effectiveness of venom immunotherapy (VIT) for the prevention of anaphylactic reactions in patients with Hymenoptera allergy, noting the potential for both VIT and EpiPen use to have negative aspects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

5.

Egg oral immunotherapy in nonanaphylactic children with egg allergy.

Author: BuchananAriana D, GreenTodd D, JonesStacie M, ScurlockAmy M, ChristieLynn, AlthageKaren A, SteelePamela H, PonsLaurent, HelmRick M, LeeLaurie A, BurksA Wesley

Safe for egg allergy

Oral immunotherapy (OIT) for egg allergy was safe and did not heighten sensitivity to egg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Specific oral tolerance induction for food. A systematic review.

Author: CalvaniM, GiorgioV, Miceli SopoS

Accelerated tolerance development
Adverse events

This systematic review examined the efficacy and safety of specific oral tolerance induction (SOTI) for treating persistent food allergy. Six randomized controlled trials (RCTs) met the inclusion criteria. SOTI showed promise in accelerating the development of tolerance, but more research is needed to optimize treatment protocols and reduce adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Oral peanut immunotherapy in children with peanut anaphylaxis.

Author: BlumchenKatharina, UlbrichtHelen, StadenUte, DobbersteinKerstin, BeschornerJohn, de OliveiraLucila Camargo Lopes, ShrefflerWayne G, SampsonHugh A, NiggemannBodo, WahnUlrich, BeyerKirsten

Peanut allergy treatment
Pulmonary obstruction

Oral immunotherapy (OIT) showed promising results in treating peanut allergy. While the initial rush protocol was less effective, a long-term buildup protocol led to a significant increase in peanut tolerance in 14 out of 22 participants. OIT was associated with a significant increase in peanut-specific serum IgG4 and a decrease in peanut-specific Th2 cytokine production. However, adverse events were observed in 2.6% of doses, including pulmonary obstruction in 1.3%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Sublingual immunotherapy for Alternaria-induced allergic rhinitis: a randomized placebo-controlled trial.

Author: CortelliniGabriele, SpadoliniIgino, PatellaVincenzo, FabbriElisabetta, SantucciAnnalisa, SeverinoMaurizio, CorvettaAngelo, CanonicaGiorgio Walter, PassalacquaGiovanni

Reduced allergy symptoms
Conjunctivitis
Oral itching

This study assessed the efficacy and safety of sublingual immunotherapy (SLIT) for Alternaria allergy. SLIT was found to be effective in improving symptoms and reducing medication intake, compared to placebo. SLIT was also safe, with only one patient reporting mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Oral immunotherapy for the treatment of peanut allergy: systematic review of six case series studies.

Author: SheikhAziz, NurmatovUlugbek, VenderboschIris, BischoffErik

Improved peanut allergy treatment

This study highlights the challenges of treating peanut allergy, for which natural resolution is rare. Peanut oral immunotherapy (OIT) is discussed as a potentially significant new treatment approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Impermeable dust mite covers in the primary and tertiary prevention of allergic disease: a meta-analysis.

Author: ArroyaveWhitney D, RabitoFelicia A, CarlsonJohn C, FriedmanEleanor E, StinebaughSarah J

Ineffective

A meta-analysis of 7 primary prevention and 17 tertiary prevention trials evaluating the effectiveness of impermeable mattress covers in the prevention and decrease of symptoms of allergic disease found no evidence to support the use of impermeable mattress covers in the primary prevention of allergic disease or in the tertiary prevention of allergic disease symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, BruschettiniMatteo, ToscaMaria Angela, ZappettiniSimona, Della Casa AlberighiOrnella, CalevoMaria Grazia

Desensitization to egg allergen
Adverse effects
Epinephrine use

Oral immunotherapy (OIT) for egg allergy was found to be effective in desensitizing a large number of egg-allergic patients. Thirty-nine percent of OIT participants could tolerate a full serving of egg compared to 11.9% of the control group. However, OIT was associated with a high frequency of mild-to-severe adverse effects, with 69% of participants experiencing such effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up.

Author: CaminitiLucia, PajnoGiovanni B, CrisafulliGiuseppe, ChieraFernanda, ColluraMirella, PanasciGirolamo, RuggeriPaolo, GuglielmoFrancesco, PassalacquaGiovanni

Food allergy treatment

Oral immunotherapy (OIT) is a potential treatment for food allergies in children. It's unclear whether OIT simply makes the body less sensitive to the food (desensitization), which would require continued exposure, or whether it leads to true tolerance, where the ability to eat the food would remain even after stopping treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Peanut oral immunotherapy in adolescents: study protocol for a randomized controlled trial.

Author: MichaudElodie, EvrardBertrand, PereiraBruno, RochetteEmmanuelle, BernardLise, RouzairePaul-Olivier, Gourdon-DuboisNelly, MerlinEtienne, FauquertJean-Luc

Oral immunotherapy
Peanut allergy

Oral immunotherapy (OIT) is showing promise for treating peanut allergies in children, especially adolescents who are at high risk. The study highlights the potential of OIT as a treatment option for peanut allergy, while recognizing the need for ongoing research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Immunotherapy (oral and sublingual) for food allergy to fruits.

Author: Yepes-NuñezJuan Jose, ZhangYuan, Roqué i FigulsMarta, Bartra TomasJoan, ReyesJuan Manuel, Pineda de la LosaFernando, EnriqueErnesto

Food allergy treatment
Anaphylaxis risk

Food allergy is an immune system reaction to food. The main treatment is avoiding the allergen, including fruits. Accidental exposure can cause severe reactions. Allergen-specific immunotherapy (SIT) is an option for people who can't avoid the allergen. Recent research focuses on oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) to treat food allergies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy.

Author: WoodRobert A, KimJennifer S, LindbladRobert, NadeauKari, HenningAlice K, DawsonPeter, PlautMarshall, SampsonHugh A

Reduced allergic reactions

A double-blind, placebo-controlled trial of 57 children with milk allergy found that omalizumab significantly reduced treatment-related adverse reactions during oral immunotherapy (OIT) but did not improve desensitization or sustained unresponsiveness (SU) outcomes. Omalizumab-treated subjects experienced fewer dose-related reactions requiring treatment and needed fewer doses to achieve maintenance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

17.

SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis.

Author: DahlRonald, RobertsGraham, de BlicJacques, CanonicaG Walter, Kleine-TebbeJörg, NolteHendrik, LawtonSimon, NelsonHarold S

SQ Timothy grass SLIT for ARC

This research examines sublingual immunotherapy (SLIT) with a SQ Timothy grass tablet for treating allergic rhinoconjunctivitis (ARC). The study highlights the effectiveness of SLIT as a treatment option for grass pollen-induced ARC.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Pragmatic randomized controlled trial of an allergy intervention for children aged 6-16 with asthma and rhinitis in general practice.

Author: SmithH, HorneyD, JonesC, GoubetS, MukhopadhyayS, FrewA

Asthma treatment
Rhinitis treatment

While avoiding specific allergens can help manage asthma and allergies, these conditions are often treated without a clear understanding of the child's specific triggers. This means that treatment decisions are often based on guesswork, and allergy avoidance advice is either not given or not tailored to the individual child's needs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.

Author: VickeryBrian P, BerglundJelena P, BurkCaitlin M, FineJason P, KimEdwin H, KimJung In, KeetCorinne A, KulisMichael, OrgelKelly G, GuoRishu, SteelePamela H, VirkudYamini V, YePing, WrightBenjamin L, WoodRobert A, BurksA Wesley

Peanut allergy treatment
Reduced peanut-specific IgE
Allergic side effects

Early oral immunotherapy (E-OIT) was found to be safe, effective, and feasible in treating peanut allergy in children aged 9 to 36 months. The study enrolled 40 children with suspected or known peanut allergy who were randomized to receive E-OIT at maintenance doses of 300 or 3000 mg/d. A high proportion of children achieved sustained unresponsiveness, with significant declines in peanut-specific IgE levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis.

Author: NayakAnjuli S, BergerWilliam E, LaForceCraig F, UrdanetaEduardo R, PatelMitesh K, FranklinKathleen B, WuMei-Miau

Reduced SAR symptoms
Headache
Pharyngitis
Somnolence

Cetirizine 10 mg was more effective than placebo in treating seasonal allergic rhinitis (SAR) symptoms in children ages 6-11 years. Loratadine 10 mg was not significantly different from placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, ToscaMaria Angela, ZappettiniSimona, CalevoMaria Grazia

Complete recovery
Increased tolerance
Mild-to-severe adverse events
Serious allergic reactions

Oral immunotherapy is an effective treatment for egg allergy in children, although it is associated with a high rate of adverse events. Most children receiving oral immunotherapy were able to ingest a partial serving of egg and almost half were able to tolerate a full serving of egg, compared to a minority of control group children. However, nearly all children who received oral immunotherapy experienced adverse events, including serious allergic reactions requiring epinephrine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Clinical and immunological profile of children aged 5-9 years with persistent egg allergy before oral immunotherapy with egg. A multicenter, randomized controlled trial of the Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology (SEICAP).

Author: EcheverriaL, Martin-MuñozM F, MartorellC, BelverM T, Alonso LebreroE, ZapateroL, FuentesV, PiquéM, PlazaA, MuñozC, MartorellA, BlascoC, VillaB, GómezC, NevotS, GarcíaJ M, MaderoR

EA treatment
OIT

Egg allergy is common in children, but the chances of outgrowing it decrease with age. This can negatively impact a child's quality of life. Oral immunotherapy (OIT) is a potential treatment that involves gradually introducing small amounts of the allergen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

AR101 Oral Immunotherapy for Peanut Allergy.

Author: , VickeryBrian P, VeredaAndrea, CasaleThomas B, BeyerKirsten, du ToitGeorge, HourihaneJonathan O, JonesStacie M, ShrefflerWayne G, MarcantonioAnnette, ZawadzkiRezi, SherLawrence, CarrWarner W, FinemanStanley, GreosLeon, RachidRima, IbáñezM Dolores, TillesStephen, Assa’adAmal H, NilssonCaroline, RuppNed, WelchMichael J, SussmanGordon, ChinthrajahSharon, BlumchenKatharina, SherEllen, SpergelJonathan M, LeicklyFrederick E, ZielenStefan, WangJulie, SandersGeorgiana M, WoodRobert A, CheemaAmarjit, Bindslev-JensenCarsten, LeonardStephanie, KachruRita, JohnstonDouglas T, HampelFrank C, KimEdwin H, AnagnostouAikaterini, PongracicJacqueline A, Ben-ShoshanMoshe, SharmaHemant P, StillermanAllan, WindomHugh H, YangWilliam H, MuraroAntonella, ZubeldiaJosé M, SharmaVibha, DorseyMorna J, ChongHey J, OhayonJason, BirdJ Andrew, CarrTara F, SiriDareen, Fernández-RivasMontserrat, JeongDavid K, FleischerDavid M, LiebermanJay A, DuboisAnthony E J, TsoumaniMarina, CiaccioChristina E, PortnoyJay M, MansfieldLyndon E, FritzStephen B, LanserBruce J, MatzJonathan, Oude ElberinkHanneke N G, VarshneyPooja, DillyStephen G, AdelmanDaniel C, BurksA Wesley

Peanut allergy treatment
Symptom severity
Adverse events

Treatment with AR101, a peanut-derived investigational biologic oral immunotherapy drug, resulted in higher doses of peanut protein that could be ingested without dose-limiting symptoms and in lower symptom severity during peanut exposure than placebo in children and adolescents with peanut allergy. Efficacy was not demonstrated in adults.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Efficacy and safety of baked milk oral immunotherapy in children with severe milk allergy: A randomized, double-blind, placebo-controlled phase 2 trial.

Author: DantzerJennifer, DunlopJoan, PsoterKevin J, KeetCorinne, WoodRobert

Desensitization
Dose-related reactions

Baked milk oral immunotherapy (BMOIT) was well tolerated and induced a substantial level of desensitization in children allergic to baked milk, with 73% of participants tolerating 4044 mg of baked milk protein after 12 months.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Biologicals in IgE-mediated food allergy.

Author: MutarelliAntonio, Giavina-BianchiBruna, ArasiStefania, CafarottiArianna, FiocchiAlessandro

Effective for food allergy

Omalizumab is a safe and effective treatment for IgE-mediated food allergy. A systematic review and meta-analysis showed that omalizumab can be used as a monotherapy or as an adjunct to oral immunotherapy in IgE-mediated cow's milk allergy. Further research is needed to evaluate other potential biologic therapies for food allergy.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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