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Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.

Author: BerglundJelena P, BurkCaitlin M, BurksA Wesley, FineJason P, GuoRishu, KeetCorinne A, KimEdwin H, KimJung In, KulisMichael, OrgelKelly G, SteelePamela H, VickeryBrian P, VirkudYamini V, WoodRobert A, WrightBenjamin L, YePing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Early oral immunotherapy (E-OIT) was found to be safe, effective, and feasible in treating peanut allergy in children aged 9 to 36 months. The study enrolled 40 children with suspected or known peanut allergy who were randomized to receive E-OIT at maintenance doses of 300 or 3000 mg/d. A high proportion of children achieved sustained unresponsiveness, with significant declines in peanut-specific IgE levels.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Oral immunotherapy (OIT) is an effective experimental food allergy treatment that is limited by treatment withdrawal and the frequent reversibility of desensitization if interrupted. Newly diagnosed preschool children may have clinical and immunological characteristics more amenable to t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27522159

データ提供：米国国立医学図書館（NLM）

Peanut Allergy: A New Frontier in Food Allergy Treatment

Peanut allergy is a common and potentially life-threatening condition, often requiring strict avoidance of peanuts. This study investigates the effectiveness of early oral immunotherapy (E-OIT) in treating peanut allergy in preschool children, exploring a potential approach for achieving long-lasting desensitization. The authors explored the safety and efficacy of E-OIT in this vulnerable population.

Early Intervention: A Promising Pathway to Peanut Tolerance

The study found that E-OIT was highly effective in inducing peanut tolerance in preschool children with peanut allergy, allowing them to safely consume peanut without allergic reactions. The authors also found that E-OIT was generally safe and well-tolerated. Imagine a camel caravan traversing a challenging desert landscape, where the camels are gradually introduced to the desert environment, building their tolerance and resilience over time. This research suggests that E-OIT could offer a similar pathway for building tolerance to peanuts in children with peanut allergy.

Shaping the Future of Food Allergy Treatment

This study offers a hopeful glimpse into the future of food allergy treatment. The authors demonstrate the potential for E-OIT to effectively desensitize children with peanut allergy, potentially reducing the burden of this condition. This research is a reminder that even in the seemingly insurmountable desert of food allergies, there are new oases of hope waiting to be discovered. This research opens up new possibilities for exploring the potential of E-OIT for treating other food allergies as well.

Dr.Camel's Conclusion

This study provides compelling evidence for the effectiveness and safety of early oral immunotherapy in treating peanut allergy in preschool children. The authors demonstrate that E-OIT can effectively desensitize children, allowing them to safely consume peanut without allergic reactions. This research offers a promising new approach to food allergy treatment, with the potential to improve the lives of children with peanut allergy and their families. It's a testament to the power of early intervention and the ongoing quest to discover new treatments for challenging health conditions.
Date :
  1. Date Completed 2017-07-19
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

27522159

DOI: Digital Object Identifier

NIHMS808639

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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