Effects of azelastine nasal spray: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Main research findings

Azelastine nasal spray has been shown to be effective in treating seasonal allergic rhinitis in numerous studies. 1 reported that azelastine significantly improved seasonal allergic rhinitis symptoms compared to placebo. 7 found that azelastine nasal spray was equally effective in improving seasonal allergic rhinitis symptoms compared to oral cetirizine. Furthermore, 26 suggests that azelastine nasal spray can be effective in patients who remain symptomatic after treatment with fexofenadine. 21 showed the potential for a once-daily dose of azelastine with a higher concentration of 0.15%. These studies suggest that azelastine nasal spray is a promising treatment option for improving seasonal allergic rhinitis symptoms.

Benefits and risks

Benefit Summary

Azelastine nasal spray offers numerous benefits for improving seasonal allergic rhinitis symptoms. Key benefits include:

  • Improvement in symptoms such as nasal congestion, runny nose, sneezing, and itchy nose
  • Rapid onset of action
  • Effects lasting 12 to 24 hours
  • Lower risk of side effects like drowsiness compared to oral antihistamines, leading to better tolerability
  • Potential effectiveness for patients who do not respond well to other antihistamines like fexofenadine

Risk Summary

Risks associated with using azelastine nasal spray include:

  • Nasal irritation, bitter taste, and nasal discomfort
  • Rare reports of side effects such as headache, drowsiness, and taste disturbances
  • Potential impact on the nasal mucosa with long-term use of nasal sprays

Comparison across studies

Similarities across studies

Multiple studies have consistently demonstrated that azelastine nasal spray effectively improves symptoms of seasonal allergic rhinitis. 1 , 7 , 26 , 21 , 20 and other studies have shown significant improvements compared to placebo. Additionally, 7 and 28 suggest azelastine nasal spray is as effective as oral cetirizine and other antihistamines.

Differences across studies

Studies vary in terms of the magnitude of azelastine’s effects, the frequency of side effects, the method of administration, and the specific patient populations studied. For example, 21 indicates the possibility of once-daily dosing with a higher concentration of azelastine. 29 confirms the safety of azelastine nasal spray over a 4-week period.

Consistency and contradictions in the results

Numerous studies consistently demonstrate that azelastine nasal spray is an effective treatment for improving seasonal allergic rhinitis symptoms. However, there are variations in the reported extent of effectiveness and frequency of side effects among studies. These variations are likely due to factors such as study design, patient populations, specific azelastine formulations, and administration methods. It is crucial to consult a doctor when using azelastine nasal spray to ensure appropriate administration and address any potential concerns.

Considerations for real-world application

Azelastine nasal spray is widely used by many individuals to manage seasonal allergic rhinitis symptoms. However, it is essential to remember that it may not be effective for all patients and side effects are possible. Therefore, careful considerations are crucial when using azelastine nasal spray. Remember to:

  • Use azelastine nasal spray as directed by your doctor.
  • Thoroughly read the accompanying leaflet before using it.
  • Consult your doctor immediately if you experience any side effects.
  • Consult your doctor if you are pregnant or breastfeeding.

Limitations of current research

Current research on azelastine nasal spray is not yet exhaustive. There is a lack of studies evaluating long-term efficacy and safety. Further research is needed to definitively establish how azelastine nasal spray compares to other treatment options in terms of effectiveness.

Future directions for research

Future studies should focus on evaluating long-term efficacy and safety. Comparative research with other treatments can help to determine the effectiveness of azelastine nasal spray. Research investigating optimal administration methods and ways to minimize side effects is also needed.

Conclusion

Numerous studies support the effectiveness of azelastine nasal spray in improving seasonal allergic rhinitis symptoms. This medication has the potential to alleviate symptoms such as nasal congestion, runny nose, sneezing, and itchy nose. However, it is important to remember that side effects are possible. Consult your doctor to ensure appropriate administration and address any potential concerns. Future research will provide even more insights into the use of azelastine nasal spray.

Literature analysis of 29 papers
Positive Content
29
Neutral Content
0
Negative Content
0
Article Type
23
0
0
3
29
1.

Azelastine nasal spray in the management of seasonal allergic rhinitis.

Author: MeltzerE O, WeilerJ M, DockhornR J, WidlitzM D, FreitagJ J

Treat allergic rhinitis
Mild side effects

Azelastine, a novel antiallergy medication, was evaluated for its efficacy in treating seasonal allergic rhinitis. Azelastine significantly reduced rhinitis symptoms compared to placebo, demonstrating a rapid onset of action and lasting up to 24 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis.

Author: GastparH, NolteD, AurichR, BrendtP, EnzmannH, GiesemannG, KunkelG, PetzoldU, RenzW, SchataM

Treat allergic rhinitis
Nasal irritation

This study compared the efficacy and tolerability of intranasal azelastine and oral terfenadine in treating allergic rhinitis. Both treatments were effective in reducing rhinitis symptoms, with no significant differences between them, suggesting that azelastine may be a viable alternative to oral terfenadine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Investigation on the efficacy and tolerance of azelastine (HCL) nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis.

Author: Conde HernándezJ, Palma AguilarJ L, Delgado RomeroJ

Effective rhinitis treatment
Good tolerance
Minimal adverse effects

Azelastine nasal spray was as effective as Ebastine tablets in treating seasonal allergic rhinitis. Both drugs had good tolerance and minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparative efficacy of steroid nasal spray versus antihistamine nasal spray in allergic rhinitis.

Author: GhimireAnand, DasBalabhadra Prasad, MishraSubhash Chandra

Allergic rhinitis relief
Azelastine efficacy
Drug side effects

Azelastine nasal spray was found to be as effective as beclomethasone nasal spray in treating allergic rhinitis symptoms. The study included 75 patients and found that both treatments reduced the Total Rhinitis Symptom Complex (TSC) score by 84% after 4 weeks. No significant adverse effects were observed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Efficacy and safety of azelastine 0.15% nasal spray administered once daily in patients with allergy to Texas mountain cedar pollen.

Author: HowlandWilliam C, AmarNiran J, WheelerWilliam, SacksHarry

SAR treatment

This study evaluated the efficacy of azelastine 0.15% nasal spray administered once daily for treating symptoms of seasonal allergic rhinitis (SAR).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Efficacy and safety of azelastine nasal spray for the treatment of allergic rhinitis.

Author: GoldenS J, CraigT J

Allergic rhinitis relief
Nasal congestion reduction
Drowsiness
Headache

Azelastine nasal spray is an effective treatment for allergic rhinitis. It has a rapid onset, long duration of action, and minimal systemic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis.

Author: CorrenJonathan, StormsWilliam, BernsteinJonathan, BergerWilliam, NayakAnjuli, SacksHarry,

Improved quality of life
Symptom relief

Azelastine nasal spray was more effective than cetirizine in reducing total nasal symptom scores and improving quality of life in patients with moderate to severe seasonal allergic rhinitis. Azelastine also had a faster onset of action than cetirizine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Evaluation of olopatadine hydrochloride nasal spray, 0.6%, used in combination with an intranasal corticosteroid in seasonal allergic rhinitis.

Author: LaForceCraig F, CarrWarner, TillesStephen A, ChippsBradley E, StormsWilliam, MeltzerEli O, EdwardsMichael

SAR symptom relief
Safety

This study evaluated the safety and efficacy of olopatadine hydrochloride nasal spray, 0.6% (OLO), administered in combination with fluticasone nasal spray, 50 micrograms (FNS), relative to azelastine nasal spray, 0.1% (AZE), administered in combination with FNS in the treatment of SAR. OLO, when administered adjunctively with FNS, is effective, safe, and well-tolerated in patients with SAR.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity.

Author: CiprandiG, PronzatoC, PassalacquaG, RiccaV, GrögenJ, MelaG S, VareseP, BertoliniC, BagnascoM, CanonicaG W

Reduced ICAM-1 expression
Reduced eosinophil infiltration
Reduced symptoms

Azelastine nasal spray significantly decreased total symptom score, eosinophilic and neutrophilic infiltration, and ICAM-1 expression during both early- and late-phase reactions in patients with pollen allergy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis.

Author: LiebermanPhil, KalinerMichael A, WheelerWilliam J

Allergic rhinitis treatment

This study evaluated the effectiveness of azelastine nasal spray, a topical second-generation antihistamine, for the treatment of seasonal allergic rhinitis, seasonal allergic rhinitis with nonallergic triggers, and nonallergic vasomotor rhinitis. The study found that azelastine nasal spray was effective in relieving symptoms of all three conditions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis.

Author: LiebermanPhillip L, SettipaneRussell A

Treat nonallergic vasomotor rhinitis
Treat seasonal allergic rhinitis

This article reviews the pharmacological profile, clinical efficacy, and safety of azelastine nasal spray for the treatment of seasonal allergic rhinitis and nonallergic vasomotor rhinitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Evaluation of the drug monitoring programme of azelastine hydrochloride nasal spray in the treatment of allergic rhinitis in children under 13 years of age.

Author: WoberW, Diez CrespoC D, BähreM

Reduced rhinitis symptoms
Adverse events

Azelastine nasal spray is effective and well-tolerated in children with allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Efficacy and safety of azelastine 0.15% nasal spray administered once daily in patients with allergy to Texas mountain cedar pollen.

Author: HowlandWilliam C, AmarNiran J, WheelerWilliam, SacksHarry

SAR treatment

This study evaluated the efficacy of azelastine 0.15% nasal spray administered once daily for treating symptoms of seasonal allergic rhinitis (SAR).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Azelastine nasal spray as adjunctive therapy to azelastine tablets in the management of seasonal allergic rhinitis.

Author: WeilerJ M, MeltzerE O

Rapid onset
Rhinitis relief
Sustained efficacy
Well tolerated

Azelastine nasal spray effectively relieved symptoms of seasonal allergic rhinitis when administered as adjunctive therapy to azelastine tablets in patients who remained symptomatic despite oral medication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model.

Author: WeilerJ M, MeltzerE O, BensonP M, WeilerK, WidlitzM D, FreitagJ

Effective rhinitis treatment
Safe rhinitis treatment

Azelastine nasal spray was effective in treating seasonal allergic rhinitis, with onset of action within 2 to 3 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Topical active H1-antihistamines and their effect on nasal airway resistance.

Author: van HoutenR J, PremachandraD J

Avoids systemic adverse effects
Rapid action
Increased nasal airway resistance

Azelastine nasal spray, a topically active H1-antihistamine, was studied for its effect on nasal airway resistance in 12 healthy volunteers. The study found a statistically significant increase in total nasal airway resistance after using Azelastine nasal spray, but there was no subjective change in nasal airway resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Sequential therapy with azelastine in seasonal allergic rhinitis. Deutsche Rhinitis Studiengruppe (German Rhinitis Study Group).

Author: KremerB, KlimekL, GülicherD, DegenM, MösgesR

Allergic rhinitis symptom relief

This study evaluated a sequential therapy regimen using azelastine, a medication for seasonal allergic rhinitis. The study found that a combination of azelastine tablets and nasal spray was more effective in relieving symptoms than nasal spray alone in the early stages of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Azelastine nasal spray in the management of seasonal allergic rhinitis.

Author: MeltzerE O, WeilerJ M, DockhornR J, WidlitzM D, FreitagJ J

Treat allergic rhinitis
Mild side effects

Azelastine, a novel antiallergy medication, was evaluated for its efficacy in treating seasonal allergic rhinitis. Azelastine significantly reduced rhinitis symptoms compared to placebo, demonstrating a rapid onset of action and lasting up to 24 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

A placebo controlled study comparing the efficacy of intranasal azelastine and beclomethasone in the treatment of seasonal allergic rhinitis.

Author: Newson-SmithG, PowellM, BaehreM, GarnhamS P, MacMahonM T

Effective treatment
Rapid symptom relief

Azelastine nasal spray provided rapid onset of symptom relief for seasonal rhinitis compared to beclomethasone, although beclomethasone showed greater improvement over time. Both were effective compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Double-blind trials of azelastine nasal spray monotherapy versus combination therapy with loratadine tablets and beclomethasone nasal spray in patients with seasonal allergic rhinitis. Rhinitis Study Groups.

Author: BergerW E, FinemanS M, LiebermanP, MilesR M

Seasonal allergic rhinitis treatment

Azelastine hydrochloride is an H1-receptor antagonist with antiinflammatory properties. It can be used for the treatment of seasonal allergic rhinitis, either as monotherapy or in combination with intranasal corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Efficacy and safety of azelastine 0.15% nasal spray administered once daily in subjects with seasonal allergic rhinitis.

Author: van BavelJulius, HowlandWilliam C, AmarN J, WheelerWilliam, SacksHarry

Azelastine nasal spray efficacy
Seasonal allergic rhinitis treatment
Bitter taste
Nasal discomfort

Azelastine 0.15% nasal spray was effective and well tolerated in subjects with seasonal allergic rhinitis (SAR) with once-daily dosing. Azelastine 0.15% nasal spray improved nasal congestion, runny nose, itchy nose, and sneezing in patients with SAR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability.

Author: BernsteinJonathan A

Rapid onset of action
Rhinitis relief
Bitter taste
Somnolence

Azelastine nasal spray, a second-generation intranasal antihistamine, effectively improved nasal symptoms associated with seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR). Azelastine provided a rapid onset of action and was generally well tolerated. Combining azelastine with fluticasone propionate nasal spray offered significantly greater relief than either agent alone in patients with SAR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Comparison of azelastine versus triamcinolone nasal spray in allergic and nonallergic rhinitis.

Author: KalpakliogluAyse Fusun, KavutAyse Baccioglu

Improves quality of life
Improves sleepiness
Reduces nasal symptoms
Bitter taste

Azelastine nasal spray was found to be as effective as triamcinolone acetonide nasal spray in treating both allergic rhinitis (AR) and nonallergic rhinitis (NAR). Both medications improved symptom scores, nasal peak inspiratory flow rate, and quality of life, but azelastine was more effective in reducing ocular symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis.

Author: LiebermanPhil, MeltzerEli O, LaForceCraig F, DarterAmy L, TortMaria J

Allergic rhinitis
Vasomotor rhinitis
Taste disturbance

Olopatadine hydrochloride nasal spray 0.6% showed comparable efficacy and safety to azelastine nasal spray 137 micrograms in treating nonallergic vasomotor rhinitis in patients aged 12 years and older. Both medications effectively reduced nasal symptoms, and no serious adverse events were reported.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Comparative efficacy of steroid nasal spray versus antihistamine nasal spray in allergic rhinitis.

Author: GhimireAnand, DasBalabhadra Prasad, MishraSubhash Chandra

Allergic rhinitis relief
Azelastine efficacy
Drug side effects

Azelastine nasal spray was found to be as effective as beclomethasone nasal spray in treating allergic rhinitis symptoms. The study included 75 patients and found that both treatments reduced the Total Rhinitis Symptom Complex (TSC) score by 84% after 4 weeks. No significant adverse effects were observed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine.

Author: LaForceCraig F, CorrenJonathan, WheelerWilliam J, BergerWilliam E,

Improved rhinitis symptoms

Azelastine nasal spray is effective monotherapy for patients with seasonal allergic rhinitis who remain symptomatic after treatment with fexofenadine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis.

Author: BanovC H, LiebermanP,

allergic rhinitis treatment

Azelastine hydrochloride, an antihistamine with anti-inflammatory properties, is currently available as a nasal spray for treating seasonal allergic rhinitis. Its potential use in treating vasomotor rhinitis, a nonallergic rhinitis, is being explored.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

A comparison of azelastine nasal spray and cetirizine tablets in the treatment of allergic rhinitis.

Author: PassaliD, PiragineF

Allergic rhinitis relief
Somnolence

Azelastine and cetirizine are both effective in relieving the symptoms of perennial allergic rhinitis. Azelastine may be slightly more effective than cetirizine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Safety and efficacy of azelastine nasal spray (Astelin NS) for seasonal allergic rhinitis: a 4-week comparative multicenter trial.

Author: LaForceC, DockhornR J, PrennerB M, ChuT J, KraemerM J, WidlitzM D, D'ElettoT A, FreitagJ J

Azelastine for rhinitis

Azelastine nasal spray demonstrated broad clinical antirhinitis activity that for the 2 sprays/nostril bid dosage regimen was consistently clinically and statistically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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