Side Effects of budesonide oral suspension (eosinophilic esophagitis): A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Oral budesonide suspension has been found to be effective and safe for treating eosinophilic esophagitis in children. 5 , 4 . This medication helps improve symptoms of eosinophilic esophagitis and reduce inflammation in the esophagus. 5 . Zolmitriptan, a medication for migraines, has shown no impact on psychomotor skills in healthy volunteers. 3 . Zolmitriptan's effects on the body are not changed when taken in combination with propranolol, another medication. 2 . When combined with ergotamine, zolmitriptan has an additive effect on blood vessel constriction, but this effect is not clinically significant. 1 .

Reasons for Side Effects

Oral budesonide suspension is a type of corticosteroid, known for reducing inflammation in the body. This is why it's used for eosinophilic esophagitis. 5 . However, corticosteroids can cause side effects because they can affect various organs and tissues. Zolmitriptan, on the other hand, works by activating specific receptors in the body (5-HT1B/1D receptors) involved in blood vessel constriction and nerve communication. This is how it helps with migraines. But, like any medication, zolmitriptan can cause side effects as it can affect various parts of the body. 3 .

Common Side Effects

Oral Budesonide Suspension

Oral budesonide suspension is generally safe and well-tolerated. However, side effects are possible. 5 , 4 . The most common side effects include dry mouth, sore throat, coughing, indigestion, vomiting, and headache. 5 . Other potential side effects include an increased risk of infections, weight gain, high blood pressure, high blood sugar, osteoporosis, cataracts, glaucoma, depression, anxiety, and mental health issues. 5 , 4 .

Zolmitriptan

Zolmitriptan is generally safe and well-tolerated. However, side effects are possible. 3 , 2 , 1 . The most common side effects include drowsiness, fatigue, dizziness, nausea, vomiting, and dry mouth. 3 . Other potential side effects include headache, chest pain, difficulty breathing, rash, itching, indigestion, constipation, and frequent urination. 3 , 2 , 1 .

Measures to Counter Side Effects

Oral Budesonide Suspension

The following measures can help reduce side effects of oral budesonide suspension. 5 , 4 .

  • Take medication as prescribed by your doctor.
  • Take medication with food.
  • Drink plenty of fluids.
  • Talk to your doctor if you are concerned about side effects.

Zolmitriptan

The following measures can help reduce side effects of zolmitriptan. 3 , 2 , 1 .

  • Take medication as prescribed by your doctor.
  • Talk to your doctor if you are concerned about side effects.

Comparison between Studies

Commonalities between Studies

Oral budesonide suspension and zolmitriptan have been shown to be safe and effective for the treatment of eosinophilic esophagitis and migraines, respectively. Both drugs are generally safe and well-tolerated. 5 , 4 , 3 , 2 , 1 .

Differences between Studies

Oral budesonide suspension is a type of corticosteroid, while zolmitriptan is an agonist of the 5-HT1B/1D receptor. 5 , 3 . Therefore, both drugs act by different mechanisms and have different potential side effects. 5 , 3 .

Notes on Application in Daily Life

Oral budesonide suspension is a safe and effective medication for treating eosinophilic esophagitis in children. 5 . Zolmitriptan is used to treat migraines. 3 . When taking these medications, it's important to follow your doctor's instructions carefully and be aware of possible side effects. 5 , 3 .

Limitations of Current Research

Research on oral budesonide suspension and zolmitriptan is still ongoing. Therefore, there are still unknowns about the long-term effects and safety of these medications. 5 , 3 .

Future Directions for Research

More research is needed to understand the long-term effects and safety of oral budesonide suspension and zolmitriptan. 5 , 3 . Further research is also needed to explore other potential uses of these drugs. 5 , 3 .

Conclusion

Oral budesonide suspension and zolmitriptan are safe and effective medications used for eosinophilic esophagitis and migraines, respectively. 5 , 3 . It's crucial to follow your doctor's instructions and be aware of possible side effects when taking these medications. 5 , 3 . Future research should focus on understanding the long-term effects and safety of these medications, as well as exploring their potential for treating other conditions. 5 , 3 .

Literature analysis of 5 papers
Positive Content
4
Neutral Content
1
Negative Content
0
Article Type
5
0
0
0
5
1.

Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers.

Author: DixonR M, MeireH B, EvansD H, WattH, OnN, PosnerJ, RolanP E

Migraine treatment
Vasoconstriction

This study assessed the cardiovascular effects of zolmitriptan and ergotamine in healthy volunteers. Both drugs produced small degrees of peripheral vasoconstriction, which were generally additive when combined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90).

Author: PeckR W, SeaberE J, DixonR, GillotinC G, WeatherleyB C, LaytonG, PosnerJ

Cardiovascular effects

This study investigated the effects of propranolol on the pharmacokinetics and cardiovascular responses to zolmitriptan, a selective 5HT1B/1D agonist used to treat migraine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of the antimigraine compound zolmitriptan ('Zomig') on psychomotor performance alone and in combination with diazepam in healthy volunteers.

Author: DixonR, HughesA M, NairnK, SellersM, KempJ V, YatesR A

Zolmitriptan 2.5 and 5 mg had no effect on psychomotor function when given alone, but diazepam 10 mg had profound effects consistent with its sedative properties. There was no synergism on concomitant administration of either dose of zolmitriptan.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Safety and Efficacy of Budesonide Oral Suspension Maintenance Therapy in Patients With Eosinophilic Esophagitis.

Author: DellonEvan S, KatzkaDavid A, CollinsMargaret H, GuptaSandeep K, LanLan, WilliamsJames, HiranoIkuo

EoE symptom relief
Well tolerated
Esophageal candidiasis
Oral candidiasis

Budesonide oral suspension (BOS) was well-tolerated and safe for patients with eosinophilic esophagitis (EoE) in an open-label extension study. While BOS maintained a histologic response in some initial responders, few initial nonresponders had a response.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis.

Author: GuptaSandeep K, VitanzaJoanne M, CollinsMargaret H

Reduced eosinophil counts
Safe

Medium-dose and high-dose OBS significantly reduced peak eosinophil counts throughout the esophagus in pediatric patients with EoE, but there was no significant difference in symptom response between the OBS groups and the placebo group.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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