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Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers.

Author: DixonR M, EvansD H, MeireH B, OnN, PosnerJ, RolanP E, WattH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study assessed the cardiovascular effects of zolmitriptan and ergotamine in healthy volunteers. Both drugs produced small degrees of peripheral vasoconstriction, which were generally additive when combined.
Paper Details　
Original Abstract of the Article :
Members of the new class of antimigraine compounds, 5HT1B/1D agonists, as well as ergotamine, may cause vasoconstriction through stimulation of 5HT receptors on peripheral vessels. The cardiovascular effects of 20 mg oral zolmitriptan (Zomig, formerly 311C90), 2 mg oral ergotamine and the combinatio...See full text at original site
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引用元：
https://doi.org/10.1046/j.1468-2982.1997.1706639.x

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1997-12-09
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

9350383

DOI: Digital Object Identifier

10.1046/j.1468-2982.1997.1706639.x

SNS
PICO Info
in preparation
Languages

English

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