Side Effects of cefadroxil: A Synthesis of Findings from 26 Studies

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Original Abstract of the Article

Main Research Findings

Cefadroxil is an oral cephalosporin antibiotic that is used to treat a variety of bacterial infections. Many studies have shown that cefadroxil is effective in treating respiratory tract infections, urinary tract infections, skin infections, scarlet fever, and other infections. 5 , 8 , 11 , 12 , 25 , 20 , 23 , 14 , 17 , 13 , 10 , 7 , 6 , 16 , 21 , 15 , 18 , 2 , 26 , 24 , 22 , 19 , 9

Reasons for side effects

Like other antibiotics, cefadroxil can cause side effects. Side effects are believed to occur because cefadroxil affects the body's immune system. Cefadroxil may also reduce the number of good bacteria in the gut, which can lead to gastrointestinal side effects such as diarrhea.

Common side effects

Gastrointestinal

Cefadroxil can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal pain. 5 , 8 , 11 , 12 , 23 , 14 , 13 , 10 , 7 , 6 , 15 , 19

Allergic Reactions

Cefadroxil can cause allergic reactions. Allergic reactions may manifest as hives, rash, itching, or difficulty breathing. 5 , 11 , 12 , 10 , 15 , 19

Liver Dysfunction

Cefadroxil can cause liver dysfunction. 11 , 12 , 15

Kidney Dysfunction

Cefadroxil can cause kidney dysfunction. People with impaired kidney function or the elderly should be especially careful. 15

Other Side Effects

Cefadroxil can also cause side effects such as dizziness, headache, fever, and fatigue. 11 , 12 , 10 , 15 , 19

Side Effects Management

Gastrointestinal

If you are concerned about gastrointestinal side effects, take cefadroxil with food or drink plenty of fluids. If symptoms are severe, consult your doctor. 5 , 11 , 12 , 23 , 14 , 13 , 10 , 7 , 6 , 15 , 19

Allergic Reactions

If you experience an allergic reaction, stop taking cefadroxil immediately and consult your doctor. 5 , 11 , 12 , 10 , 15 , 19

Liver Dysfunction

If you suspect liver dysfunction, stop taking cefadroxil and consult your doctor. It is also important to have regular liver function tests. 11 , 12 , 15

Kidney Dysfunction

If you have kidney dysfunction, consult your doctor before taking cefadroxil. Your doctor may need to adjust the amount or frequency of cefadroxil you take. 15

Other Side Effects

If you experience side effects such as dizziness, headache, fever, or fatigue while taking cefadroxil, consult your doctor. If symptoms are severe, you may need to stop taking cefadroxil. 11 , 12 , 10 , 15 , 19

Comparison of studies

Commonalities of studies

Many studies have shown that cefadroxil is effective in treating a variety of bacterial infections. Cefadroxil is generally considered to be a safe drug.

Differences between studies

Studies have shown that the types of infections for which cefadroxil is effective and the incidence of side effects vary depending on the study. Studies comparing cefadroxil to other antibiotics have shown that cefadroxil has differences in efficacy and side effects compared to other antibiotics.

Cautions for real-life application

It is important to take cefadroxil as directed by your doctor. Do not stop taking cefadroxil or adjust the dosage without consulting your doctor. Also, tell your doctor if you are pregnant or breastfeeding before taking cefadroxil. Cefadroxil should be used with caution in people with allergies. Tell your doctor if you have a history of allergies before taking cefadroxil.

Limitations of current research

Research on cefadroxil is still insufficient. In particular, further research is needed on the effects of long-term use.

Future research directions

Research on cefadroxil needs to be further studied in a variety of areas, including the effects of long-term use, comparisons with other antibiotics, and the mechanisms of side effects.

Conclusion

Cefadroxil is an oral cephalosporin antibiotic that is effective in treating a variety of bacterial infections. Cefadroxil is generally considered to be a safe drug, but it can cause side effects. When taking cefadroxil, follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Keywords
Benefit Keywords
Analgesic properties
Glutamate recycling
1
Sepsis treatment
2
URTI treatment
3
Safe pregnancy treatment
4
Effective for respiratory infections
5
Effective for pneumococcal pneumonia
6
Respiratory infection treatment
7
UTI treatment
8
Good clinical evaluation
9
Scarlet fever treatment
Upper respiratory tract infection treatment
10
Antibacterial activity
Scarlet fever treatment
11
Febrile diseases treatment
Respiratory tract infection treatment
12
Good cutaneous distribution
Pediatric infections treatment
13
Good absorption
Upper respiratory tract infection treatment
14
Effective for pediatric infectious disease
Good clinical results
15
Effective ENT infection treatment
16
Convenient dosage
Effective UTI treatment
High cure rate
17
Effective treatment
Well tolerated
18
Clinical success
Patient compliance
19
Clinical success
Well tolerated
20
Urinary infection treatment
21
Pharyngitis treatment
22
Chronic bronchitis treatment
23
Flare-up prevention
24
Cefadroxil for UTI
Nitrofurantoin for UTI
25
Reduced infection rate
Shorter hospital stay
26
Risk Keywords
Adverse effects
Treatment failure
2
Overuse of antibiotics
Side effects
3
Teratogenicity
4
Gastrointestinal disturbance
Hypersensitivity reaction
5
Diarrhea
6
Gastrointestinal side effects
8
Similar side effects
9
GOT/GPT increase
Slight vomiting
11
Slight diarrhea
12
Digestive tract disorders
14
Diarrhea
Elevated serum transaminase
Eosinophilia
15
Few side effects
17
Reinfection
18
Side effects
19
Mild and transient side effects
20
Relapse
22
Nausea
Vomiting
23
Gastrointestinal side effects
24
Nitrofurantoin side effects
25
No side effects reported
26
Literature analysis of 26 papers
Positive Content
25
Neutral Content
1
Negative Content
0
Article Type
9
0
0
1
26
2.

Ampicillin plus mecillinam vs. cefotaxime/cefadroxil treatment of patients with severe pneumonia or pyelonephritis: a double-blind multicentre study evaluated by intention-to-treat analysis.

Author: CronbergS, BankeS, BrunoA M, CarlssonM, ElmrudH, ElowssonS, JosefssonK, LindholmA C, MonteliusH, NeringerR

Sepsis treatment
Adverse effects
Treatment failure

Ampicillin and mecillinam (A+M) were as effective as cefotaxime followed by cefadroxil in treating febrile patients with sepsis and signs of pneumonia or pyelonephritis. However, both treatment groups had a high rate of treatment failure. Side effects were reported in 22% of patients in the A+M group and 28% in the cephalosporin group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Cefadroxil compared with cefaclor in the treatment of streptococcal pneumonia in adults.

Author: ZeLuffB, CatchpoleM, LoweP, KoornhofH, GentryL

Effective for pneumococcal pneumonia
Diarrhea

Cefadroxil and cefaclor were effective in treating pneumococcal pneumonia in gold miners. Both antibiotics demonstrated high efficacy and good tolerance, suggesting their potential for treating respiratory tract infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A comparative study of cefadroxil and co-trimoxazole in patients with lower respiratory tract infections.

Author: CastroM

Respiratory infection treatment

Cefadroxil and co-trimoxazole were compared in 42 patients with lower respiratory tract infections. Both antibiotics achieved similar overall cure rates (67% and 60%, respectively) and reduced sputum purulence. No serious side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Effect of cefadroxil in urinary tract infections].

Author: IwaoN, KajikawaH, KameokaH, HosokawaS, NishimotoN, MiyoshiS, MizutaniS

UTI treatment
Gastrointestinal side effects

Cefadroxil (CDX) was found to be effective in treating urinary tract infections. The effectiveness rate was 95% for simple UTIs and 57% for complicated UTIs. The most common side effects were gastrointestinal upset and allergic reactions.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

9.

[Double-blind comparison of cefadroxil and cephalexin granules in the treatment of impetigo].

Author: ArataJ, NoharaN, SuwakiM, UmemuraS, NakagawaS, MiyoshiK, YamamotoY, NishiharaO, YamadaM, HiramatsuH

Good clinical evaluation
Similar side effects

Cefadroxil was slightly better than cephalexin in treating impetigo in children, but the difference was not statistically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

10.

[Some investigations on cefadroxil dry syrup (author's transl)].

Author: NakazawaS, SatoH, NiinoK, SuzukiH, IwasakiA, HiramaY, NaritaA, ChikaokaH, YamaguchiT

Scarlet fever treatment
Upper respiratory tract infection treatment

Cefadroxil, an antibiotic, showed good in vitro activity against various bacteria, including A group beta-Streptococcus. It was effective in treating various infections in children, including scarlet fever and upper respiratory tract infections, with a high efficacy rate and a low incidence of side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

16.

[Therapeutical experience of cefadroxil against acute infectious diseases in the otorhinolaryngological field (author's transl)].

Author: NagabaM

Effective ENT infection treatment

Cefadroxil was highly effective and safe in treating otorhinolaryngological infections. 100% of patients experienced excellent or good outcomes.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

17.

Treatment of urinary infections with cefadroxil: controlled comparison of high-compliance oral dosage regimens.

Author: HausmanM S

Convenient dosage
Effective UTI treatment
High cure rate
Few side effects

Cefadroxil is an effective treatment for urinary tract infections. It is well tolerated and has few side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Clinical comparison of cefadroxil, new oral cephalosporin, and cephalexin in uncomplicated urinary tract infection.

Author: BoldingO T

Effective treatment
Well tolerated
Reinfection

Cefadroxil was as effective as cephalexin in treating acute urinary tract infections in women. Cefadroxil 1,000 mg given twice daily was as effective and as well tolerated as cephalexin 500 mg given four times daily.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

An overview of results of world-wide clinical trials with cefadroxil.

Author: SantellaP J, TanriseverB, BermanE

Clinical success
Patient compliance
Side effects

Cefadroxil, a new semisynthetic oral cephalosporin, was effective in treating a variety of infections, including respiratory tract infections and genito-urinary tract infections. Cefadroxil achieved a 91.8% clinical success rate in 1030 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Clinical experience with cefadroxil in upper and lower respiratory tract infections.

Author: MercadoF F, SantellaP J, FernandezC A

Clinical success
Well tolerated
Mild and transient side effects

Cefadroxil, a new oral cephalosporin, was effective in treating upper and lower respiratory tract infections. Cefadroxil achieved a 93% cure rate in 108 patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

[Treatment of urinary infection with cephadroxyl (Pharmachem)--microbiological and clinical research].

Author: MinkovN, ZlatanovZ, ZozikovB, KhristovaD

Urinary infection treatment

Cephadroxyl was found to be effective in treating urinary tract infections in renal patients. The most sensitive bacteria were E. coli, Klebsiella sp., Enterobacter sp., P. mirabilis, and Citrobacter sp. Side effects were mild and rare.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Bulgarian

22.

Once-daily cefadroxil versus oral penicillin in the pediatric treatment of streptococcal pharyngitis.

Author: GoldfarbJ, LemonE, O'HoroJ, BlumerJ L

Pharyngitis treatment
Relapse

Cefadroxil and penicillin V potassium were equally effective in treating pharyngitis, with cure rates of 100% and 88%, respectively. Both treatments had low rates of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A randomised, prospective, single-blind comparison of cefadroxil and amoxycillin in the treatment of acute exacerbations of chronic bronchitis.

Author: BintA J, CefaiC, McGhieD, PereraB S

Chronic bronchitis treatment
Nausea
Vomiting

Cefadroxil 1 g twice daily and amoxycillin 500 mg three times a day were equally effective in treating acute exacerbations of chronic bronchitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

A comparison of erythromycin and cefadroxil in the prevention of flare-ups from asymptomatic teeth with pulpal necrosis and associated periapical pathosis.

Author: MorseD R, FurstM L, LefkowitzR D, D'AngeloD, EspositoJ V

Flare-up prevention
Gastrointestinal side effects

Cefadroxil is as effective as erythromycin and penicillin in preventing flare-ups after endodontic treatment of asymptomatic teeth with pulpal necrosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Antibiotic prophylaxis following lower urinary tract instrumentation.

Author: BhatiaN N, KarramM M, BergmanA, EvansR P

Cefadroxil for UTI
Nitrofurantoin for UTI
Nitrofurantoin side effects

Cefadroxil was more effective in preventing postinstrumentation urinary tract infections than placebo and was better tolerated than nitrofurantoin in women undergoing lower urinary tract instrumentation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Prevention of postoperative infection in cesarean section after rupture of the membranes.

Author: SchedvinsK, MobergP J

Reduced infection rate
Shorter hospital stay
No side effects reported

Prophylactic use of cefuroxime followed by cefadroxil significantly reduced the infection rate in patients undergoing cesarean section after prolonged rupture of membranes. The antibiotic regimen was well tolerated with no reported side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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