Side Effects of dihydroergotamine nasal spray: A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Major findings

Dihydroergotamine nasal spray is effective and safe for treating acute migraine attacks. 1 . The American Headache Society considers dihydroergotamine nasal spray an effective option for acute migraine treatment, ranking it as Level A evidence. 3 . Using this spray early in the prodromal phase of migraine is also linked to improved efficacy. 2 .

Reason for side effects

Dihydroergotamine's vasoconstrictive properties can lead to side effects like nasal inflammation and vasoconstriction. 2 .

Common side effects

Nasal irritation

The most common side effect reported with dihydroergotamine nasal spray is nasal irritation. 2 . This is likely due to the drug's vasoconstrictive effects on the nasal mucosa. Symptoms can include nasal congestion, burning, and stinging.

Gastrointestinal symptoms

Dihydroergotamine may also cause digestive issues. 2 . Nausea, vomiting, and stomach pain are possible side effects.

Dizziness

Dizziness is another potential side effect of dihydroergotamine. 2 .

Measures to address side effects

Nasal irritation

To minimize nasal irritation, consider rinsing your nasal passages before using the spray or gently wiping your nose afterward. 2 .

Gastrointestinal symptoms

If digestive discomfort is a concern, try eating a meal before using the nasal spray or staying hydrated after application. 2 .

Dizziness

After using dihydroergotamine nasal spray, take some time to rest and avoid activities that require focus or coordination if dizziness is a concern. 2 .

Comparison between studies

Commonalities between studies

All three studies agree that dihydroergotamine nasal spray is effective for acute migraine treatment. They also consistently report side effects like nasal irritation, gastrointestinal symptoms, and dizziness.

Differences between studies

1 and 2 are clinical studies evaluating the efficacy and safety of dihydroergotamine nasal spray. 3 is a review article compiling evidence for various acute migraine treatments, including dihydroergotamine nasal spray.

Precautions for application in real life

While dihydroergotamine nasal spray is an effective treatment option for acute migraine, it's important to be aware of potential side effects. Always consult your doctor before using this medication and discuss any health conditions you may have. This is especially important for pregnant or breastfeeding women, and individuals with pre-existing conditions like heart disease or liver disease.

Limitations of current research

Further research is needed to fully understand the long-term safety of dihydroergotamine nasal spray.

Future research directions

Ongoing research should focus on the long-term safety and efficacy of dihydroergotamine nasal spray. Determining the optimal dosage and administration method for this medication is also crucial.

Conclusion

Dihydroergotamine nasal spray is a valuable treatment option for acute migraine, but potential side effects should be considered. Consult your doctor before using this medication to ensure it's appropriate for you and to learn about proper use. Remember that while it's effective, side effects can occur, so stay informed and seek medical advice as needed.

Literature analysis of 3 papers
Positive Content
3
Neutral Content
0
Negative Content
0
Article Type
1
0
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1
3
1.

Dihydroergotamine nasal spray in the treatment of acute migraine.

Author: TrevesT A, KuritzkyA, HeringR, KorczynA D

Migraine relief
Side effects

Dihydroergotamine (DHE) nasal spray was found to be well tolerated and to have dose-dependent efficacy in migraine. Patients taking DHE used less rescue medications, and the tolerability of the drug was assessed as good by 94% of the patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Dihydroergotamine as a nasal spray in the therapy of migraine attacks. Efficacy and tolerance].

Author: JenzerG, BremgartnerM F

Migraine relief
Dizziness
Nasal irritation
Nausea
Vomiting

Dihydroergotamine nasal spray was found to be effective in treating acute migraine attacks in 76.8% of patients. Good efficacy was obtained by 63% of patients who used the nasal spray in the prodromal phase. Side effects such as nasal irritation, nausea, dizziness, and vomiting were reported by 18.1% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : German

3.

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.

Author: MarmuraMichael J, SilbersteinStephen D, SchwedtTodd J

Migraine treatment
Opioid use

This review provides an updated assessment of the evidence for pharmacological therapies used to treat acute migraine attacks. The study focused on medications available from 1998 to 2013 and evaluated their effectiveness based on the level of evidence. Triptans and dihydroergotamine are effective (Level A). Ergotamine and other forms of dihydroergotamine are likely effective (Level B). Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, sumatriptan/naproxen, and acetaminophen/aspirin/caffeine are effective nonspecific medications (Level A). Ketoprofen, intravenous and intramuscular ketorolac, flurbiprofen, intravenous magnesium, and the combination of isometheptene compounds, codeine/acetaminophen, and tramadol/acetaminophen are likely effective (Level B). Antiemetics prochlorperazine, droperidol, chlorpromazine, and metoclopramide are also likely effective (Level B). While opioids like butorphanol, codeine/acetaminophen, and tramadol/acetaminophen are probably effective, they are not recommended for regular use due to their potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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