Side Effects of diphenhydramine topical: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Diphenhydramine topical is a medication used to treat allergy symptoms. It is also used to treat radiation and chemotherapy-induced stomatitis. 4 reports a case of a five-year-old child who experienced hallucinations and other side effects after excessive application of commercially available diphenhydramine topical preparation for varicella treatment. However, 7 and 8 suggest that diphenhydramine topical is not absorbed through the skin.

Reasons for Side Effects

Diphenhydramine topical is an antihistamine medication that works by blocking histamine, a chemical that causes allergic reactions. However, antihistamines can also affect the central nervous system, which can cause side effects such as drowsiness, dizziness, and difficulty concentrating. Antihistamines also have anticholinergic effects, which can lead to side effects such as dry mouth, constipation, and difficulty urinating.

Common Side Effects

Drowsiness

Diphenhydramine topical can cause drowsiness. 4 reports a case of a five-year-old child who experienced hallucinations and other side effects after excessive application of commercially available diphenhydramine topical preparation for varicella treatment. This side effect may have been caused by the effect of diphenhydramine topical on the central nervous system.

Dizziness

Diphenhydramine topical can cause dizziness.

Difficulty Concentrating

Diphenhydramine topical can cause difficulty concentrating. This side effect may be caused by the effect of diphenhydramine topical on the central nervous system.

Dry Mouth

Diphenhydramine topical can cause dry mouth. This is due to the anticholinergic effects of diphenhydramine topical.

Constipation

Diphenhydramine topical can cause constipation. This is due to the anticholinergic effects of diphenhydramine topical.

Difficulty Urinating

Diphenhydramine topical can cause difficulty urinating. This is due to the anticholinergic effects of diphenhydramine topical.

Side Effect Management

Drowsiness

Avoid driving or operating machinery that requires alertness if you are taking diphenhydramine topical. Also, avoid alcohol while using diphenhydramine topical.

Dizziness

When getting up from a lying down or sitting position, get up slowly to avoid dizziness.

Difficulty Concentrating

Avoid driving or operating machinery that requires alertness if you are taking diphenhydramine topical.

Dry Mouth

Drink plenty of fluids to prevent dry mouth.

Constipation

Eat foods high in fiber and drink plenty of fluids to prevent constipation.

Difficulty Urinating

Go to the bathroom as soon as you feel the urge to urinate. Also, it is important to drink plenty of fluids.

Comparison of Studies

Commonalities

Diphenhydramine topical is used to treat allergy symptoms and radiation and chemotherapy-induced stomatitis.

Differences

The results of studies regarding the side effects of diphenhydramine topical vary. For example, 4 reports a case of a five-year-old child who experienced hallucinations and other side effects after excessive application of commercially available diphenhydramine topical preparation for varicella treatment. However, 7 and 8 suggest that diphenhydramine topical is not absorbed through the skin.

Considerations for Real-Life Applications

Diphenhydramine topical is an effective medication for treating allergy symptoms and radiation and chemotherapy-induced stomatitis. However, it can cause side effects so it is important to use it as directed by a doctor. This is especially important for children, older adults, and pregnant or breastfeeding women.

Limitations of Current Research

There is not enough research on the side effects of diphenhydramine topical. Further studies are needed, especially on the long-term effects of diphenhydramine topical use.

Future Research Directions

Further research on the side effects of diphenhydramine topical is needed. This includes detailed studies on the long-term effects of its use, its effects on children, older adults, and pregnant or breastfeeding women, and its potential interactions with other medications.

Conclusion

Diphenhydramine topical can be an effective medication for treating allergy symptoms and radiation and chemotherapy-induced stomatitis. However, it can cause side effects, so it is important to use it as directed by a doctor. If you experience any side effects, talk to your doctor right away.

Literature analysis of 8 papers
Positive Content
6
Neutral Content
1
Negative Content
1
Article Type
4
0
0
1
8
1.

Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers.

Author: DixonR M, MeireH B, EvansD H, WattH, OnN, PosnerJ, RolanP E

Migraine treatment
Vasoconstriction

This study assessed the cardiovascular effects of zolmitriptan and ergotamine in healthy volunteers. Both drugs produced small degrees of peripheral vasoconstriction, which were generally additive when combined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90).

Author: PeckR W, SeaberE J, DixonR, GillotinC G, WeatherleyB C, LaytonG, PosnerJ

Cardiovascular effects

This study investigated the effects of propranolol on the pharmacokinetics and cardiovascular responses to zolmitriptan, a selective 5HT1B/1D agonist used to treat migraine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of the antimigraine compound zolmitriptan ('Zomig') on psychomotor performance alone and in combination with diazepam in healthy volunteers.

Author: DixonR, HughesA M, NairnK, SellersM, KempJ V, YatesR A

Zolmitriptan 2.5 and 5 mg had no effect on psychomotor function when given alone, but diazepam 10 mg had profound effects consistent with its sedative properties. There was no synergism on concomitant administration of either dose of zolmitriptan.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Topical diphenhydramine toxicity in a five year old with varicella.

Author: WoodwardG A, BaldassanoR N

Hallucinations
Side effects

A case report details a five-year-old child with varicella who experienced hallucinations and other side effects after applying a commercially available topical diphenhydramine preparation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

[Allergy in pregnancy].

Author: Di LorenzoG, MansuetoP, MellusoM, Purello D'AmbrosioF, PutignanoE, Barbagallo SangiorgiG

Safe for pregnancy

The study provides a summary of drug recommendations for allergy treatment during pregnancy. It highlights that no drug is considered completely safe during pregnancy, and recommends various medications with relatively lower risks.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

6.

Treatment of radiation- and chemotherapy-induced stomatitis.

Author: CarnelS B, BlakesleeD B, OswaldS G, BarnesM

Pain relief
Stomatitis treatment
None reported

Dyclonine hydrochloride 1.0% was the most effective topical solution for pain relief from radiation- or chemotherapy-induced stomatitis. Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, averaging 50 minutes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A randomized trial of the effectiveness of topical "ABH Gel" (Ativan(®), Benadryl(®), Haldol(®)) vs. placebo in cancer patients with nausea.

Author: FletcherDevon S, CoynePatrick J, DodsonPatricia W, ParkerGwendolyn G, WanWen, SmithThomas J

Nausea treatment
Limited scientific data

ABH gel, a topical gel containing lorazepam, diphenhydramine, and haloperidol, is often used for nausea but lacks scientific evidence for its effectiveness. Further research is needed to understand why it is perceived to be effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

ABH gel is not absorbed from the skin of normal volunteers.

Author: SmithThomas J, RitterJoseph K, PoklisJustin L, FletcherDevon, CoynePatrick J, DodsonPatricia, ParkerGwendolyn

Nausea treatment
Drug absorption

This study examined whether lorazepam, diphenhydramine, and haloperidol (ABH) topical gel drugs are absorbed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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